Detailed information of TA system TA187252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4658856..4659327
• Replicon: chromosome
• Accession: NZ_CP068444
• Organism: Klebsiella quasipneumoniae strain SWMUF35

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IT777_RS22450
• Protein ID: WP_104466681.1
• Coordinates: 4658856..4659095 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: IT777_RS22455
• Protein ID: WP_023291757.1
• Coordinates: 4659085..4659327 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT777_RS22440	4655809..4657947	+	2139	WP_188028165.1	anaerobic ribonucleoside-triphosphate reductase	-
IT777_RS22445	4658343..4658807	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IT777_RS22450	4658856..4659095	-	240	WP_104466681.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IT777_RS22455	4659085..4659327	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IT777_RS22460	4659405..4661315	-	1911	WP_117145827.1	BglG family transcription antiterminator	-
IT777_RS22465	4661338..4662489	-	1152	WP_072421254.1	lactonase family protein	-
IT777_RS22470	4662556..4663296	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9171.73 Da
• Isoelectric Point: 10.1315

>T187252 WP_104466681.1 NZ_CP068444:c4659095-4658856 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWHKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Nucleotide

• Length: 240 bp

>T187252 NZ_CP089780:2189543-2189920 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT187252 WP_023291757.1 NZ_CP068444:c4659327-4659085 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT187252 NZ_CP089780:2189962-2190411 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86