Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 712103..712881 Replicon chromosome
Accession NZ_CP068444
Organism Klebsiella quasipneumoniae strain SWMUF35

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag IT777_RS03520 Protein ID WP_135732963.1
Coordinates 712393..712881 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag IT777_RS03515 Protein ID WP_135732964.1
Coordinates 712103..712396 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT777_RS03495 707311..707913 - 603 WP_032454058.1 short chain dehydrogenase -
IT777_RS03500 708011..708922 + 912 WP_135732966.1 LysR family transcriptional regulator -
IT777_RS03505 708923..710071 - 1149 WP_135732965.1 PLP-dependent aspartate aminotransferase family protein -
IT777_RS03510 710082..711458 - 1377 WP_167878556.1 cystathionine beta-synthase -
IT777_RS03515 712103..712396 + 294 WP_135732964.1 DUF1778 domain-containing protein Antitoxin
IT777_RS03520 712393..712881 + 489 WP_135732963.1 GNAT family N-acetyltransferase Toxin
IT777_RS03525 712946..713644 + 699 WP_188028144.1 hypothetical protein -
IT777_RS03530 713759..715453 - 1695 WP_135732635.1 hypothetical protein -
IT777_RS03535 715450..717360 - 1911 WP_188028143.1 hypothetical protein -
IT777_RS03540 717619..717840 + 222 Protein_695 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 706492..717360 10868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17684.61 Da        Isoelectric Point: 7.3253

>T187239 WP_135732963.1 NZ_CP068444:712393-712881 [Klebsiella quasipneumoniae]
MISAPEPLHTGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGHGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVE
SI

Download         Length: 489 bp

>T187239 NZ_CP089780:840194-840622 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10942.55 Da        Isoelectric Point: 8.6141

>AT187239 WP_135732964.1 NZ_CP068444:712103-712396 [Klebsiella quasipneumoniae]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIILADPQAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT187239 NZ_CP089780:839913-840170 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References