Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 241397..242307 Replicon plasmid unnamed3
Accession NZ_CP068443
Organism Pantoea agglomerans strain ZJU23

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JK642_RS21970 Protein ID WP_069026891.1
Coordinates 241837..242307 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JK642_RS21965 Protein ID WP_064703869.1
Coordinates 241397..241840 (+) Length 148 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK642_RS21935 (JK642_21870) 236466..237314 - 849 WP_189327956.1 transporter substrate-binding domain-containing protein -
JK642_RS21940 (JK642_21875) 237336..238523 - 1188 WP_235765477.1 M20 family metallopeptidase -
JK642_RS21945 (JK642_21880) 238765..239664 - 900 WP_235765478.1 alpha/beta hydrolase -
JK642_RS21950 (JK642_21885) 239715..240329 - 615 WP_235765479.1 TetR/AcrR family transcriptional regulator -
JK642_RS21955 (JK642_21890) 240543..240960 + 418 Protein_232 LysR substrate-binding domain-containing protein -
JK642_RS21960 (JK642_21895) 240995..241252 - 258 Protein_233 aldo/keto reductase -
JK642_RS21965 (JK642_21900) 241397..241840 + 444 WP_064703869.1 DUF2384 domain-containing protein Antitoxin
JK642_RS21970 (JK642_21905) 241837..242307 + 471 WP_069026891.1 RES family NAD+ phosphorylase Toxin
JK642_RS21975 (JK642_21910) 242479..243510 + 1032 WP_010670602.1 AI-2E family transporter -
JK642_RS21980 (JK642_21915) 243499..246228 - 2730 WP_182687108.1 cation-transporting P-type ATPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..567588 567588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-148)

Antitoxin

(16-147)


Sequences


Toxin        


Download         Length: 157 a.a.        Molecular weight: 17466.90 Da        Isoelectric Point: 4.7699

>T187236 WP_069026891.1 NZ_CP068443:241837-242307 [Pantoea agglomerans]
MILYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDALIQTADIT
ELPANWADEDAPAELADYGDAWCSACDAVALRVPSALSPVEYNYLLNPEHPDFFRIVQQAEAIPFRFDRRLKPDRK

Download         Length: 471 bp

>T187236 NZ_CP089780:c753978-753670 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16463.84 Da        Isoelectric Point: 9.9250

>AT187236 WP_064703869.1 NZ_CP068443:241397-241840 [Pantoea agglomerans]
MKTFSFSANKTRAPRLWQAAGLNNADGVALLGQINEGLDGNVAHLIVNWAKITQNDLRKMSGIPSTTFSRSVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKMPAELMASETGAYEVMKLITRLEHGVYS

Download         Length: 444 bp

>AT187236 NZ_CP089780:c754210-753965 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References