Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 154374..154900 Replicon plasmid unnamed2
Accession NZ_CP068442
Organism Pantoea agglomerans strain ZJU23

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JK642_RS20725 Protein ID WP_069027133.1
Coordinates 154613..154900 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JK642_RS20720 Protein ID WP_069027132.1
Coordinates 154374..154613 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK642_RS20705 (JK642_20655) 150221..150889 + 669 WP_064703131.1 DUF2268 domain-containing putative Zn-dependent protease -
JK642_RS20710 (JK642_20660) 150939..151955 - 1017 WP_039387390.1 NAD(P)-dependent alcohol dehydrogenase -
JK642_RS20715 (JK642_20665) 152060..154033 - 1974 WP_235765268.1 methyl-accepting chemotaxis protein -
JK642_RS20720 (JK642_20670) 154374..154613 + 240 WP_069027132.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JK642_RS20725 (JK642_20675) 154613..154900 + 288 WP_069027133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JK642_RS20730 (JK642_20680) 154945..155241 - 297 WP_039387382.1 hypothetical protein -
JK642_RS20735 (JK642_20685) 155443..155619 + 177 WP_010257023.1 KGG domain-containing protein -
JK642_RS20740 (JK642_20690) 155683..156579 - 897 WP_069027134.1 LysR family transcriptional regulator -
JK642_RS20745 (JK642_20695) 156713..157906 + 1194 WP_069027135.1 MFS transporter -
JK642_RS20750 (JK642_20700) 157975..159000 + 1026 WP_182687976.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..170989 170989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-75)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11053.99 Da        Isoelectric Point: 10.2591

>T187235 WP_069027133.1 NZ_CP068442:154613-154900 [Pantoea agglomerans]
MPWQLECDQRALKEWRKLGPTVREQLKKKLAECLESPRIEANKLSRMPDCYKIKLKSSGYRLAYQVIDDRVVVFVVAVGK
RERSEICSAASRRLS

Download         Length: 288 bp

>T187235 NZ_CP089780:c752352-751969 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8894.31 Da        Isoelectric Point: 8.6146

>AT187235 WP_069027132.1 NZ_CP068442:154374-154613 [Pantoea agglomerans]
VGSISIRIDDDLKRRSFAALKKMGVTPSDALRLMLAYIADNERPPFKQTSLSDEDAALVDIVKERLRNPEPVRITLDKL

Download         Length: 240 bp

>AT187235 NZ_CP089780:c752602-752447 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References