Detailed information of TA system TA187231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2042985..2044546
• Replicon: chromosome
• Accession: NZ_CP068440
• Organism: Pantoea agglomerans strain ZJU23

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JK642_RS09590
• Protein ID: WP_115387534.1
• Coordinates: 2042985..2044298 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JK642_RS09595
• Protein ID: WP_022625644.1
• Coordinates: 2044298..2044546 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK642_RS09570 (JK642_09540)	2038080..2038415	+	336	WP_235765100.1	gamma-glutamylcyclotransferase family protein	-
JK642_RS09575 (JK642_09545)	2038805..2040850	-	2046	WP_031592300.1	FUSC family protein	-
JK642_RS09580 (JK642_09550)	2040926..2042347	-	1422	WP_235765101.1	M24 family metallopeptidase	-
JK642_RS09585 (JK642_09555)	2042674..2042847	-	174	WP_230873490.1	type II toxin-antitoxin system MqsA family antitoxin	-
JK642_RS09590 (JK642_09560)	2042985..2044298	-	1314	WP_115387534.1	type II toxin-antitoxin system HipA family toxin	Toxin
JK642_RS09595 (JK642_09565)	2044298..2044546	-	249	WP_022625644.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JK642_RS09600 (JK642_09570)	2044726..2045163	+	438	WP_235765102.1	GNAT family N-acetyltransferase	-
JK642_RS09605 (JK642_09575)	2045197..2045991	-	795	WP_083068020.1	inositol monophosphatase family protein	-
JK642_RS09610 (JK642_09580)	2046015..2047076	-	1062	WP_083068017.1	ABC transporter ATP-binding protein	-
JK642_RS09615 (JK642_09585)	2047073..2049298	-	2226	WP_235765103.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-54)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49161.76 Da
• Isoelectric Point: 8.4280

>T187231 WP_115387534.1 NZ_CP068440:c2044298-2042985 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTAWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Nucleotide

• Length: 1314 bp

>T187231 NZ_CP089780:701918-702319 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9363.61 Da
• Isoelectric Point: 5.0775

>AT187231 WP_022625644.1 NZ_CP068440:c2044546-2044298 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEASAPQLHDED
EW

Nucleotide

• Length: 249 bp

>AT187231 NZ_CP089780:701676-701921 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA