Detailed information of TA system TA187229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 718434..719065
• Replicon: chromosome
• Accession: NZ_CP068440
• Organism: Pantoea agglomerans strain ZJU23

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JK642_RS03170
• Protein ID: WP_083070550.1
• Coordinates: 718434..718613 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JK642_RS03175
• Protein ID: WP_083070549.1
• Coordinates: 718640..719065 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK642_RS03160 (JK642_03160)	714765..716666	+	1902	WP_083070551.1	pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase	-
JK642_RS03165 (JK642_03165)	716827..718251	+	1425	WP_235765120.1	dihydrolipoyl dehydrogenase	-
JK642_RS03170 (JK642_03170)	718434..718613	+	180	WP_083070550.1	type II toxin-antitoxin system HicA family toxin	Toxin
JK642_RS03175 (JK642_03175)	718640..719065	+	426	WP_083070549.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JK642_RS03180 (JK642_03180)	719775..720674	-	900	WP_235764780.1	LysR family transcriptional regulator	-
JK642_RS03185 (JK642_03185)	720780..721289	+	510	WP_039391324.1	phenolic acid decarboxylase	-
JK642_RS03190 (JK642_03190)	721376..722233	+	858	WP_064703404.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6552.63 Da
• Isoelectric Point: 11.0668

>T187229 WP_083070550.1 NZ_CP068440:718434-718613 [Pantoea agglomerans]
MDSSTLISEMKADGWVLTRINGSHHHFTHPTKPGLVTVPHPKKDLPVGTVKSIRKQARI

Nucleotide

• Length: 180 bp

>T187229 NZ_CP089780:c693663-693271 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15420.62 Da
• Isoelectric Point: 4.7662

>AT187229 WP_083070549.1 NZ_CP068440:718640-719065 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAADTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIEALATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQIALERITAPINRPQK

Nucleotide

• Length: 426 bp

>AT187229 NZ_CP089780:c693917-693660 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA