Detailed information of TA system TA187227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4942686..4944289
• Replicon: chromosome
• Accession: NZ_CP068437
• Organism: Shewanella sp. KX20019

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JK628_RS21395
• Protein ID: WP_202286912.1
• Coordinates: 4942686..4944008 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JK628_RS21400
• Protein ID: WP_202286913.1
• Coordinates: 4944008..4944289 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK628_RS21380	4938414..4939145	+	732	WP_202286909.1	M48 family metallopeptidase	-
JK628_RS21385	4939145..4941670	+	2526	WP_202286910.1	N-6 DNA methylase	-
JK628_RS21390	4941670..4942419	+	750	WP_202286911.1	hypothetical protein	-
JK628_RS21395	4942686..4944008	-	1323	WP_202286912.1	type II toxin-antitoxin system HipA family toxin	Toxin
JK628_RS21400	4944008..4944289	-	282	WP_202286913.1	helix-turn-helix domain-containing protein	Antitoxin
JK628_RS21405	4944704..4945342	+	639	WP_202286914.1	multidrug MFS transporter	-
JK628_RS21410	4945361..4946055	-	695	Protein_4155	amino acid adenylation	-
JK628_RS21415	4946494..4946865	+	372	WP_202286915.1	metalloregulator ArsR/SmtB family transcription factor	-
JK628_RS21420	4946919..4947623	-	705	WP_202286916.1	4Fe-4S dicluster domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-400)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49107.94 Da
• Isoelectric Point: 8.7451

>T187227 WP_202286912.1 NZ_CP068437:c4944008-4942686 [Shewanella sp. KX20019]
MAVLDVYMNGYLVGGFTKSTTGFHLFQYAAQWLSTPNSRPISLSMPLRKKAYKGDEVYNFFDNLLPDNIEVRNRIVARHN
AQSTQAFDLLAKIGQDSVGALQLVACGQKAFDIKKIESKPLSDTALEKVLKGYQSGIPLGMLAEEDDFRISIAGAQEKTA
LLNLDGQWRLPIKATPTTHIIKLPIGEIQSHSHTIDMPDSVENEYLCMMIVREFGLDVPHCSIIRVGDIKALAVERFDRR
LSSDGKWIMRLPQEDFCQTLNIPAAKKYESHGGPGIEKIMPYLLGSRNAEQDRYDFMKSQVLFWLLAATDGHAKNFSLFI
EAGAGYRLTPFYDILSMYPVIGGKGLNIRDAKLAMGLKATKGKKYQVAQIFPRHFMQTAKAVGFDVAAMSAIMREIASSV
DLVMEKVQAQLPDSFPVYIRDAILDGLKIRSKRLVDKEGC

Nucleotide

• Length: 1323 bp

>T187227 NZ_CP089780:c639077-638664 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10680.25 Da
• Isoelectric Point: 10.0110

>AT187227 WP_202286913.1 NZ_CP068437:c4944289-4944008 [Shewanella sp. KX20019]
MKVTNSKQLSAYLKDARLNMKLSQSKVAHKVGIRQDTVSSFEQNPGSTKLETLFKILSALNLELDIKVRNPELASKLLDD
RTMSSDREWKEEW

Nucleotide

• Length: 282 bp

>AT187227 NZ_CP089780:c639340-639074 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA