Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 104874..105457 Replicon plasmid p1
Accession NZ_CP068436
Organism Cupriavidus necator isolate XXL

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJQ59_RS33730 Protein ID WP_114136211.1
Coordinates 104874..105254 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JJQ59_RS33735 Protein ID WP_114136212.1
Coordinates 105251..105457 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ59_RS33710 100708..102504 + 1797 WP_114136216.1 arginine--tRNA ligase -
JJQ59_RS33715 103264..103404 - 141 Protein_103 SDR family oxidoreductase -
JJQ59_RS33720 103405..103515 - 111 Protein_104 cell filamentation protein Fic -
JJQ59_RS33725 104012..104575 - 564 WP_114136210.1 hypothetical protein -
JJQ59_RS33730 104874..105254 - 381 WP_114136211.1 type II toxin-antitoxin system VapC family toxin Toxin
JJQ59_RS33735 105251..105457 - 207 WP_114136212.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JJQ59_RS33740 105739..106035 - 297 WP_114136217.1 DUF1016 family protein -
JJQ59_RS33745 106059..107394 + 1336 Protein_109 transposase -
JJQ59_RS33750 107769..108221 - 453 WP_022537657.1 transcriptional regulator -
JJQ59_RS33755 108322..108588 + 267 WP_114135742.1 hypothetical protein -
JJQ59_RS33760 109184..109534 + 351 WP_114135741.1 DUF2958 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / htpB 1..1185855 1185855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13684.98 Da        Isoelectric Point: 6.9668

>T187225 WP_114136211.1 NZ_CP068436:c105254-104874 [Cupriavidus necator]
MSVLVDTSVWVNHFKNRNDALVNLVVSDQALTHPIVLVELACGTPPAPRVRTLGDIGLLQPAKQASLAEVMAFIEHEKLY
GLGCGLVDVSLLASTLITPGAQLWTLDKRLDDLSVRFGVAHRPKLH

Download         Length: 381 bp

>T187225 NZ_CP089780:362505-362930 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7589.64 Da        Isoelectric Point: 5.0490

>AT187225 WP_114136212.1 NZ_CP068436:c105457-105251 [Cupriavidus necator]
MRTTVTIDDALYEQALEVADPNMDKSDLFREAIKTFVRVQAAKRLAALGGAAPDMQDVPRRRTEPEAK

Download         Length: 207 bp

>AT187225 NZ_CP089780:362287-362508 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References