187223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 1158785..1159770 Replicon chromosome
Accession NZ_CP068435
Organism Cupriavidus necator isolate XXL

Toxin (Protein)


Gene name ParT Uniprot ID -
Locus tag JJQ59_RS24430 Protein ID WP_114134734.1
Coordinates 1159297..1159770 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID -
Locus tag JJQ59_RS24425 Protein ID WP_114134735.1
Coordinates 1158785..1159300 (+) Length 172 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ59_RS24395 1154218..1154862 + 645 WP_114134740.1 TetR/AcrR family transcriptional regulator -
JJQ59_RS24400 1155176..1155493 + 318 WP_147266327.1 hypothetical protein -
JJQ59_RS24405 1155571..1155753 + 183 WP_114134739.1 hypothetical protein -
JJQ59_RS24410 1155805..1156230 - 426 WP_114134738.1 hypothetical protein -
JJQ59_RS24415 1156480..1157607 - 1128 WP_114134737.1 site-specific integrase -
JJQ59_RS24420 1157721..1158686 + 966 WP_114134736.1 DNA-binding protein -
JJQ59_RS24425 1158785..1159300 + 516 WP_114134735.1 DUF2384 domain-containing protein Antitoxin
JJQ59_RS24430 1159297..1159770 + 474 WP_114134734.1 RES family NAD+ phosphorylase Toxin
JJQ59_RS24435 1159774..1161351 - 1578 WP_114134733.1 fatty acid--CoA ligase -
JJQ59_RS24440 1161547..1163856 + 2310 WP_189374534.1 ATP-dependent DNA helicase -
JJQ59_RS24445 1163981..1164304 + 324 WP_013952898.1 thioredoxin family protein -
JJQ59_RS24450 1164322..1164753 - 432 WP_114134731.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(110-168)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16777.00 Da        Isoelectric Point: 6.2181

>T187223 WP_114134734.1 NZ_CP068435:1159297-1159770 [Cupriavidus necator]
VRPAWRIATDTPDYTADDASGAGAKATGGRWNRQGTPLIYAASSIALACLETLVHLGASGLPLNRYLVRIDIPDELWAAA
QQLSADTAPVGWDAIPAGKTNLDTGQAWTAAGTSALLLVPSIVIPEEHNVLVNPTHPDAARLAYVKLRRWQYDARLV

Download         Length: 474 bp

>T187223 NZ_CP089780:361937-362239 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 172 a.a.        Molecular weight: 18481.99 Da        Isoelectric Point: 7.2047

>AT187223 WP_114134735.1 NZ_CP068435:1158785-1159300 [Cupriavidus necator]
MPLTLTPEGRYPLAHERPASPELSVNNYVAVYEASLSTQGAMSVIRAIREGVPASDLTRLAESMGTTKEQLIKTLDLPRA
TVDRKARAHQNLSSEQSERVLGMARLVGQVQALVESSGDPRGFSAAQWVAQWLEQPSPALGGRRPAELMDTLAGQRIVSD
LVARMQSGAYA

Download         Length: 516 bp

>AT187223 NZ_CP089780:361713-361940 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References