Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 1092940..1093532 Replicon chromosome
Accession NZ_CP068435
Organism Cupriavidus necator isolate XXL

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJQ59_RS24100 Protein ID WP_114133690.1
Coordinates 1092940..1093329 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JJQ59_RS24105 Protein ID WP_114133689.1
Coordinates 1093326..1093532 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ59_RS24075 1088202..1089044 - 843 WP_114136442.1 S-formylglutathione hydrolase -
JJQ59_RS24080 1089055..1090160 - 1106 Protein_1029 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
JJQ59_RS24085 1090306..1091688 - 1383 WP_114133692.1 MFS transporter -
JJQ59_RS24090 1091701..1092618 - 918 WP_114133691.1 aldo/keto reductase -
JJQ59_RS24095 1092686..1092821 + 136 Protein_1032 transposase -
JJQ59_RS24100 1092940..1093329 - 390 WP_114133690.1 type II toxin-antitoxin system VapC family toxin Toxin
JJQ59_RS24105 1093326..1093532 - 207 WP_114133689.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JJQ59_RS24110 1093643..1093828 - 186 WP_114133688.1 hypothetical protein -
JJQ59_RS24115 1094172..1094321 - 150 Protein_1036 ABC transporter substrate-binding protein -
JJQ59_RS24120 1094671..1095786 - 1116 WP_114133687.1 amino acid dehydrogenase -
JJQ59_RS24125 1096683..1097378 + 696 WP_114133686.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086052..1096481 10429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14010.24 Da        Isoelectric Point: 6.8599

>T187222 WP_114133690.1 NZ_CP068435:c1093329-1092940 [Cupriavidus necator]
MSVLVDTSVWVDHFKSRNDALVSLLVSDQALTHPMVVVELACGTPPAPRARTLGDIGLLQPARRASLAEVMAFIEQENLY
GLGCGLVDVSLLASTLITPGARLWTLDQRLNDLSARFGVAHRPRLHQVT

Download         Length: 390 bp

>T187222 NZ_CP089780:73428-73829 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7534.63 Da        Isoelectric Point: 5.0651

>AT187222 WP_114133689.1 NZ_CP068435:c1093532-1093326 [Cupriavidus necator]
MRTTVTIDDALYEQALEVADPGMDKSDLFREAIKTFVRVQAAKRLAALGGAAPNMEDAPRRRMEPEAK

Download         Length: 207 bp

>AT187222 NZ_CP089780:73196-73435 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References