Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3371265..3372097 Replicon chromosome
Accession NZ_CP068394
Organism Escherichia coli strain M-17

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag JK368_RS16215 Protein ID WP_000854753.1
Coordinates 3371723..3372097 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag JK368_RS16210 Protein ID WP_001278232.1
Coordinates 3371265..3371633 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK368_RS16180 3368101..3368556 + 456 WP_000581504.1 hypothetical protein -
JK368_RS16185 3368635..3368868 + 234 WP_001119729.1 DUF905 family protein -
JK368_RS16190 3368968..3369786 + 819 WP_001520163.1 DUF945 domain-containing protein -
JK368_RS16195 3369841..3370326 + 486 WP_001520165.1 antirestriction protein -
JK368_RS16200 3370342..3370818 + 477 WP_001186726.1 RadC family protein -
JK368_RS16205 3370881..3371102 + 222 WP_000692316.1 DUF987 domain-containing protein -
JK368_RS16210 3371265..3371633 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JK368_RS16215 3371723..3372097 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
JK368_RS16220 3372094..3372582 + 489 WP_000777541.1 hypothetical protein -
JK368_RS16225 3372594..3372791 + 198 WP_000839281.1 DUF957 domain-containing protein -
JK368_RS16230 3372888..3373457 + 570 WP_001290241.1 DUF4942 domain-containing protein -
JK368_RS16235 3373799..3373969 + 171 Protein_3180 IS110 family transposase -
JK368_RS16240 3374780..3375763 + 984 WP_001331698.1 KpsF/GutQ family sugar-phosphate isomerase -
JK368_RS16245 3375835..3376983 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T187207 WP_000854753.1 NZ_CP068394:3371723-3372097 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T187207 NZ_CP089779:3500518-3500826 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT187207 WP_001278232.1 NZ_CP068394:3371265-3371633 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT187207 NZ_CP089779:3500286-3500531 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References