Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2231481..2232312 Replicon chromosome
Accession NZ_CP068394
Organism Escherichia coli strain M-17

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JK368_RS10980 Protein ID WP_000854814.1
Coordinates 2231938..2232312 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag JK368_RS10975 Protein ID WP_001285586.1
Coordinates 2231481..2231849 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK368_RS10940 2226538..2227608 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
JK368_RS10945 2227744..2228421 + 678 WP_046960522.1 hypothetical protein -
JK368_RS10950 2228437..2228847 + 411 WP_000846704.1 hypothetical protein -
JK368_RS10955 2229068..2229889 + 822 WP_001234571.1 DUF945 domain-containing protein -
JK368_RS10960 2230152..2230625 + 474 WP_000855074.1 antirestriction protein -
JK368_RS10965 2230641..2231117 + 477 WP_001351157.1 RadC family protein -
JK368_RS10970 2231186..2231407 + 222 WP_000692323.1 DUF987 domain-containing protein -
JK368_RS10975 2231481..2231849 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JK368_RS10980 2231938..2232312 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JK368_RS10985 2232309..2232503 + 195 WP_000988601.1 hypothetical protein -
JK368_RS10990 2232516..2232629 + 114 WP_001161660.1 DUF957 domain-containing protein -
JK368_RS10995 2232918..2233064 - 147 Protein_2157 transposase domain-containing protein -
JK368_RS11000 2233118..2233300 + 183 WP_001016348.1 hypothetical protein -
JK368_RS11005 2233401..2233730 - 330 WP_000450409.1 DUF496 family protein -
JK368_RS11010 2233902..2234960 - 1059 WP_001200890.1 FUSC family protein -
JK368_RS11015 2235158..2235631 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
JK368_RS11020 2235750..2236916 - 1167 WP_001519880.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T187203 WP_000854814.1 NZ_CP068394:2231938-2232312 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T187203 NZ_CP089779:c3240494-3240060 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT187203 WP_001285586.1 NZ_CP068394:2231481-2231849 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT187203 NZ_CP089779:c3240679-3240500 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References