Detailed information of TA system TA187187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 6157069..6157658
• Replicon: chromosome
• Accession: NZ_CP068390
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain YS21

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: JHW28_RS27630
• Protein ID: WP_202338973.1
• Coordinates: 6157359..6157658 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: JHW28_RS27625
• Protein ID: WP_007924096.1
• Coordinates: 6157069..6157362 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW28_RS27605	6152631..6153794	-	1164	WP_124312230.1	acyltransferase	-
JHW28_RS27610	6153989..6155179	-	1191	WP_124309654.1	serine hydrolase	-
JHW28_RS27615	6155306..6156193	+	888	WP_135006984.1	LysR family transcriptional regulator	-
JHW28_RS27620	6156581..6156973	+	393	WP_202338972.1	hypothetical protein	-
JHW28_RS27625	6157069..6157362	-	294	WP_007924096.1	putative addiction module antidote protein	Antitoxin
JHW28_RS27630	6157359..6157658	-	300	WP_202338973.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JHW28_RS27635	6157829..6158278	+	450	WP_063433162.1	DUF3828 domain-containing protein	-
JHW28_RS27640	6158303..6159313	-	1011	WP_202340171.1	NAD(P)-dependent alcohol dehydrogenase	-
JHW28_RS27645	6159371..6159670	-	300	WP_009051080.1	ArsR family transcriptional regulator	-
JHW28_RS27650	6159734..6160825	-	1092	WP_202338974.1	nitrite reductase, copper-containing	-
JHW28_RS27655	6161051..6161293	+	243	WP_007924102.1	exodeoxyribonuclease VII small subunit	-
JHW28_RS27660	6161290..6162177	+	888	WP_038575447.1	(2E,6E)-farnesyl diphosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Uncharacterized protein HI1420 (6-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11241.09 Da
• Isoelectric Point: 9.1862

>T187187 WP_202338973.1 NZ_CP068390:c6157658-6157359 [Pseudomonas chlororaphis subsp. aurantiaca]
MIEIKQIATFMEWENRLKDPRARALIAAWIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQPCGLQLVILLCGGDKS
RQSRDIELAKYLACRWSRS

Nucleotide

• Length: 300 bp

>T187187 NZ_CP089779:2028271-2028831 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10430.94 Da
• Isoelectric Point: 5.6558

>AT187187 WP_007924096.1 NZ_CP068390:c6157362-6157069 [Pseudomonas chlororaphis subsp. aurantiaca]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Nucleotide

• Length: 294 bp

>AT187187 NZ_CP089779:2027933-2028274 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA