Detailed information of TA system TA187185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4112289..4112808
• Replicon: chromosome
• Accession: NZ_CP068390
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain YS21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JHW28_RS18420
• Protein ID: WP_162095625.1
• Coordinates: 4112289..4112570 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H3UB71
• Locus tag: JHW28_RS18425
• Protein ID: WP_009044432.1
• Coordinates: 4112560..4112808 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW28_RS18395	4107580..4107852	+	273	WP_081360544.1	hypothetical protein	-
JHW28_RS18400	4108592..4108720	-	129	Protein_3635	ATP-binding protein	-
JHW28_RS18405	4108811..4109602	+	792	WP_081360543.1	methyltransferase domain-containing protein	-
JHW28_RS18410	4109918..4110400	+	483	WP_009049637.1	acyl-CoA thioesterase	-
JHW28_RS18415	4110457..4112106	+	1650	WP_202338429.1	FMN-binding glutamate synthase family protein	-
JHW28_RS18420	4112289..4112570	-	282	WP_162095625.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JHW28_RS18425	4112560..4112808	-	249	WP_009044432.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JHW28_RS18430	4112896..4113684	-	789	WP_162095627.1	helix-turn-helix transcriptional regulator	-
JHW28_RS18435	4113769..4114767	+	999	WP_202338430.1	bile acid:sodium symporter	-
JHW28_RS18440	4114981..4116744	+	1764	WP_202338431.1	hypothetical protein	-
JHW28_RS18445	4116817..4117278	+	462	WP_009049642.1	YccF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10849.64 Da
• Isoelectric Point: 10.6282

>T187185 WP_162095625.1 NZ_CP068390:c4112570-4112289 [Pseudomonas chlororaphis subsp. aurantiaca]
MTYELEFSEKAWREWQKLGPTLKEQFKKKLQERLVNPHVPADRLSGLGNAYKIKLRTAGYRLVYRVVDEVLVVTVIAVGK
RERGSVYQQASKR

Nucleotide

• Length: 282 bp

>T187185 NZ_CP089779:c2003297-2002899 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8997.37 Da
• Isoelectric Point: 4.4142

>AT187185 WP_009044432.1 NZ_CP068390:c4112808-4112560 [Pseudomonas chlororaphis subsp. aurantiaca]
MTHVLLSNVVASISELKKNPMGTVAAGGGSSVAILNRNEPAFYCVPAKEYEAMMERLEDMELLALCRERENDPTIKVSLD
DL

Nucleotide

• Length: 249 bp

>AT187185 NZ_CP089779:c2003525-2003298 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1H3UB71