Detailed information of TA system TA187183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2322318..2322922
• Replicon: chromosome
• Accession: NZ_CP068390
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain YS21

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JHW28_RS10675
• Protein ID: WP_164485685.1
• Coordinates: 2322755..2322922 (-)
• Length: 56 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A285IZU0
• Locus tag: JHW28_RS10670
• Protein ID: WP_007923747.1
• Coordinates: 2322318..2322719 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW28_RS10655	2318179..2320068	+	1890	WP_202339678.1	PAS domain S-box protein	-
JHW28_RS10660	2320065..2320700	+	636	WP_202339679.1	response regulator transcription factor	-
JHW28_RS10665	2320794..2321558	+	765	WP_124298953.1	hypothetical protein	-
JHW28_RS10670	2322318..2322719	-	402	WP_007923747.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JHW28_RS10675	2322755..2322922	-	168	WP_164485685.1	type II toxin-antitoxin system HicA family toxin	Toxin
JHW28_RS10680	2323229..2323510	-	282	WP_202339680.1	hypothetical protein	-
JHW28_RS10685	2323908..2324264	-	357	WP_202339681.1	hypothetical protein	-
JHW28_RS10690	2324249..2324683	-	435	Protein_2097	hypothetical protein	-
JHW28_RS10695	2325035..2326864	+	1830	WP_202340111.1	hypothetical protein	-
JHW28_RS10700	2327120..2327668	-	549	WP_202339682.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-54)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 56 a.a.
• Molecular weight: 6192.28 Da
• Isoelectric Point: 10.4656

>T187183 WP_164485685.1 NZ_CP068390:c2322922-2322755 [Pseudomonas chlororaphis subsp. aurantiaca]
MIKELEAAGWVLERVTGSHHLFTHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Nucleotide

• Length: 168 bp

>T187183 NZ_CP089779:1891987-1892421 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14579.54 Da
• Isoelectric Point: 4.6017

>AT187183 WP_007923747.1 NZ_CP068390:c2322719-2322318 [Pseudomonas chlororaphis subsp. aurantiaca]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT187183 NZ_CP089779:1891726-1891980 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: A0A285IZU0