Detailed information of TA system TA187182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 318397..319067
• Replicon: chromosome
• Accession: NZ_CP068390
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain YS21

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JHW28_RS01385
• Protein ID: WP_081362979.1
• Coordinates: 318397..318825 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: JHW28_RS01390
• Protein ID: WP_009046453.1
• Coordinates: 318822..319067 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW28_RS01370	313516..315774	+	2259	WP_202339221.1	TonB-dependent receptor	-
JHW28_RS01375	315821..317146	+	1326	WP_202339222.1	LLM class flavin-dependent oxidoreductase	-
JHW28_RS01380	317231..318268	+	1038	WP_096372787.1	L-glyceraldehyde 3-phosphate reductase	-
JHW28_RS01385	318397..318825	-	429	WP_081362979.1	type II toxin-antitoxin system VapC family toxin	Toxin
JHW28_RS01390	318822..319067	-	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
JHW28_RS01395	319207..320046	-	840	WP_202339223.1	taurine dioxygenase	-
JHW28_RS01400	320274..321113	-	840	WP_009046455.1	taurine ABC transporter permease TauC	-
JHW28_RS01405	321110..321904	-	795	WP_102676415.1	taurine ABC transporter ATP-binding subunit	-
JHW28_RS01410	322000..322977	-	978	WP_202339224.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15853.36 Da
• Isoelectric Point: 5.4927

>T187182 WP_081362979.1 NZ_CP068390:c318825-318397 [Pseudomonas chlororaphis subsp. aurantiaca]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASAVAMFEEDFIDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Nucleotide

• Length: 429 bp

>T187182 NZ_CP089779:1855356-1855673 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT187182 WP_009046453.1 NZ_CP068390:c319067-318822 [Pseudomonas chlororaphis subsp. aurantiaca]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT187182 NZ_CP089779:1855144-1855359 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9