Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 311549..312162 Replicon chromosome
Accession NZ_CP068390
Organism Pseudomonas chlororaphis subsp. aurantiaca strain YS21

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JHW28_RS01355 Protein ID WP_096372784.1
Coordinates 311549..311731 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JHW28_RS01360 Protein ID WP_202340095.1
Coordinates 311761..312162 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW28_RS01325 307315..307572 - 258 WP_124307420.1 hypothetical protein -
JHW28_RS01330 307625..308113 - 489 WP_124307421.1 DoxX family protein -
JHW28_RS01335 308187..309083 - 897 WP_202339218.1 SDR family oxidoreductase -
JHW28_RS01340 309112..309621 - 510 WP_162094236.1 DUF1097 domain-containing protein -
JHW28_RS01345 309655..310395 - 741 WP_028683849.1 SDR family oxidoreductase -
JHW28_RS01350 310534..311424 + 891 WP_202339219.1 LysR family transcriptional regulator -
JHW28_RS01355 311549..311731 + 183 WP_096372784.1 type II toxin-antitoxin system HicA family toxin Toxin
JHW28_RS01360 311761..312162 + 402 WP_202340095.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JHW28_RS01365 312262..313308 - 1047 WP_202339220.1 LacI family DNA-binding transcriptional regulator -
JHW28_RS01370 313516..315774 + 2259 WP_202339221.1 TonB-dependent receptor -
JHW28_RS01375 315821..317146 + 1326 WP_202339222.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6902.07 Da        Isoelectric Point: 10.4588

>T187181 WP_096372784.1 NZ_CP068390:311549-311731 [Pseudomonas chlororaphis subsp. aurantiaca]
MRSRELIRMIEEDGWYLIAVKGSHHPYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T187181 NZ_CP089779:c1454522-1454097 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14582.41 Da        Isoelectric Point: 4.9133

>AT187181 WP_202340095.1 NZ_CP068390:311761-312162 [Pseudomonas chlororaphis subsp. aurantiaca]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPVPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT187181 NZ_CP089779:c1454749-1454528 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References