Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 73474..74129 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP068388 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | H9AC96 |
| Locus tag | JI728_RS23900 | Protein ID | WP_001746752.1 |
| Coordinates | 73701..74129 (+) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | H9AC95 |
| Locus tag | JI728_RS23895 | Protein ID | WP_001261283.1 |
| Coordinates | 73474..73704 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JI728_RS23855 (JI728_23690) | 68863..69348 | - | 486 | WP_000905606.1 | membrane protein | - |
| JI728_RS23860 (JI728_23695) | 69342..69830 | - | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| JI728_RS23865 (JI728_23700) | 70017..70568 | - | 552 | WP_079786988.1 | EAL domain-containing protein | - |
| JI728_RS23870 (JI728_23705) | 70577..71359 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| JI728_RS23875 (JI728_23710) | 71394..71915 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| JI728_RS23880 (JI728_23715) | 71912..72202 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| JI728_RS23885 (JI728_23720) | 72204..72509 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | - |
| JI728_RS23890 (JI728_23725) | 72511..72729 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| JI728_RS23895 (JI728_23730) | 73474..73704 | + | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| JI728_RS23900 (JI728_23735) | 73701..74129 | + | 429 | WP_001746752.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| JI728_RS23905 (JI728_23740) | 74699..75547 | - | 849 | WP_000175397.1 | SdiA-regulated domain-containing protein | - |
| JI728_RS23910 (JI728_23745) | 75573..75734 | - | 162 | WP_001816720.1 | hypothetical protein | - |
| JI728_RS23915 (JI728_23750) | 75995..76207 | - | 213 | WP_000063791.1 | FaeA/PapI family transcriptional regulator | - |
| JI728_RS23920 (JI728_23755) | 76280..76864 | - | 585 | WP_024138406.1 | hypothetical protein | - |
| JI728_RS23925 (JI728_23760) | 76989..77702 | - | 714 | WP_000801114.1 | hypothetical protein | - |
| JI728_RS23930 (JI728_23765) | 77964..78728 | - | 765 | WP_001746754.1 | minor fimbrial protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | spvB / spvC / fdeC / faeI / faeH | 1..86412 | 86412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15483.07 Da Isoelectric Point: 8.1325
>T187179 WP_001746752.1 NZ_CP068388:73701-74129 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MKQPRTKTYMLDTCICSFIMREKSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
MKQPRTKTYMLDTCICSFIMREKSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
Download Length: 429 bp
>T187179 NZ_CP089779:c1394678-1394265 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8737.83 Da Isoelectric Point: 4.3775
>AT187179 WP_001261283.1 NZ_CP068388:73474-73704 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT187179 NZ_CP089779:c1394226-1393969 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A764IXM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6X6R7C5 |