Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4223775..4224435 Replicon chromosome
Accession NZ_CP068386
Organism Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag JI728_RS20545 Protein ID WP_000244756.1
Coordinates 4223775..4224188 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag JI728_RS20550 Protein ID WP_000351186.1
Coordinates 4224169..4224435 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI728_RS20525 (4219716) 4219716..4221449 - 1734 WP_000813390.1 single-stranded-DNA-specific exonuclease RecJ -
JI728_RS20530 (4221455) 4221455..4222168 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JI728_RS20535 (4222192) 4222192..4223088 - 897 WP_079786799.1 site-specific tyrosine recombinase XerD -
JI728_RS20540 (4223201) 4223201..4223722 + 522 WP_001055885.1 flavodoxin FldB -
JI728_RS20545 (4223775) 4223775..4224188 - 414 WP_000244756.1 protein YgfX Toxin
JI728_RS20550 (4224169) 4224169..4224435 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
JI728_RS20555 (4224685) 4224685..4225665 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
JI728_RS20560 (4225781) 4225781..4226440 - 660 WP_000250289.1 hemolysin III family protein -
JI728_RS20565 (4226604) 4226604..4226915 - 312 WP_001182975.1 N(4)-acetylcytidine aminohydrolase -
JI728_RS20570 (4227073) 4227073..4228506 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T187176 WP_000244756.1 NZ_CP068386:c4224188-4223775 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T187176 NZ_CP089779:c1332489-1332049 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT187176 WP_000351186.1 NZ_CP068386:c4224435-4224169 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187176 NZ_CP089779:c1332763-1332476 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References