187175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4212886..4213511 Replicon chromosome
Accession NZ_CP068386
Organism Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag JI728_RS20480 Protein ID WP_000911336.1
Coordinates 4212886..4213284 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag JI728_RS20485 Protein ID WP_000557549.1
Coordinates 4213284..4213511 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI728_RS20465 (4209561) 4209561..4210142 - 582 WP_001747403.1 fimbrial protein -
JI728_RS20470 (4210861) 4210861..4211493 - 633 WP_000835265.1 YfdX family protein -
JI728_RS20475 (4211540) 4211540..4212076 - 537 WP_079786800.1 STM3031 family outer membrane protein -
JI728_RS20480 (4212886) 4212886..4213284 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
JI728_RS20485 (4213284) 4213284..4213511 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
JI728_RS20490 (4213720) 4213720..4213971 + 252 WP_001576352.1 hypothetical protein -
JI728_RS20495 (4214251) 4214251..4215057 + 807 WP_001574939.1 DUF1460 domain-containing protein -
JI728_RS20505 (4215342) 4215342..4216100 - 759 WP_020937168.1 amidase activator ActS -
JI728_RS20510 (4216365) 4216365..4216910 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
JI728_RS20515 (4216986) 4216986..4218503 - 1518 WP_000003342.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T187175 WP_000911336.1 NZ_CP068386:c4213284-4212886 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T187175 NZ_CP089779:1287282-1287605 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT187175 WP_000557549.1 NZ_CP068386:c4213511-4213284 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT187175 NZ_CP089779:1286957-1287202 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References