Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1669907..1670527 Replicon chromosome
Accession NZ_CP068386
Organism Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JI728_RS08070 Protein ID WP_001280991.1
Coordinates 1669907..1670125 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6C6Z3Y6
Locus tag JI728_RS08075 Protein ID WP_000344806.1
Coordinates 1670153..1670527 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI728_RS08030 (1665128) 1665128..1665697 + 570 WP_000779802.1 YbaY family lipoprotein -
JI728_RS08035 (1665730) 1665730..1666119 - 390 WP_000961288.1 MGMT family protein -
JI728_RS08045 (1666350) 1666350..1667900 - 1551 WP_000213140.1 EAL domain-containing protein -
JI728_RS08050 (1668125) 1668125..1668391 + 267 WP_020937098.1 type B 50S ribosomal protein L31 -
JI728_RS08055 (1668393) 1668393..1668533 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JI728_RS08060 (1668589) 1668589..1669059 - 471 WP_079786716.1 YlaC family protein -
JI728_RS08065 (1669177) 1669177..1669728 - 552 WP_001278793.1 maltose O-acetyltransferase -
JI728_RS08070 (1669907) 1669907..1670125 - 219 WP_001280991.1 HHA domain-containing protein Toxin
JI728_RS08075 (1670153) 1670153..1670527 - 375 WP_000344806.1 Hha toxicity modulator TomB Antitoxin
JI728_RS08080 (1671023) 1671023..1674172 - 3150 WP_020937097.1 efflux RND transporter permease AcrB -
JI728_RS08085 (1674195) 1674195..1675388 - 1194 WP_020937096.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T187165 WP_001280991.1 NZ_CP068386:c1670125-1669907 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T187165 NZ_CP089779:c487420-487163 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14425.25 Da        Isoelectric Point: 5.1444

>AT187165 WP_000344806.1 NZ_CP068386:c1670527-1670153 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATKANPVSLSC

Download         Length: 375 bp

>AT187165 NZ_CP089779:c487692-487417 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z3Y6

References