Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1035705..1036281 Replicon chromosome
Accession NZ_CP068386
Organism Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag JI728_RS04970 Protein ID WP_001131963.1
Coordinates 1035705..1035992 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag JI728_RS04975 Protein ID WP_000063142.1
Coordinates 1035979..1036281 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI728_RS04950 (1030859) 1030859..1030993 + 135 WP_001055725.1 hypothetical protein -
JI728_RS04955 (1031025) 1031025..1032278 - 1254 WP_001206756.1 N-6 DNA methylase -
JI728_RS04960 (1032437) 1032437..1032856 - 420 WP_001720162.1 restriction endonuclease subunit S -
JI728_RS04965 (1033469) 1033469..1035309 - 1841 Protein_967 NERD domain-containing protein -
JI728_RS04970 (1035705) 1035705..1035992 + 288 WP_001131963.1 BrnT family toxin Toxin
JI728_RS04975 (1035979) 1035979..1036281 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
JI728_RS04980 (1036356) 1036356..1037312 - 957 WP_000187842.1 GTPase -
JI728_RS04985 (1037323) 1037323..1037526 - 204 WP_000460616.1 YbdD/YjiX family protein -
JI728_RS04990 (1037639) 1037639..1039327 - 1689 Protein_972 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T187161 WP_001131963.1 NZ_CP068386:1035705-1035992 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T187161 NZ_CP089778:c3810371-3809979 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT187161 WP_000063142.1 NZ_CP068386:1035979-1036281 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT187161 NZ_CP089778:c3810646-3810371 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References