Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 196199..196959 Replicon chromosome
Accession NZ_CP068386
Organism Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag JI728_RS00925 Protein ID WP_000533909.1
Coordinates 196474..196959 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag JI728_RS00920 Protein ID WP_000965886.1
Coordinates 196199..196486 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI728_RS00900 (191604) 191604..192515 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
JI728_RS00905 (192525) 192525..194594 + 2070 WP_001291748.1 glycine--tRNA ligase subunit beta -
JI728_RS00910 (194984) 194984..195382 + 399 Protein_180 IS3 family transposase -
JI728_RS00915 (195554) 195554..196021 + 468 Protein_181 GNAT family N-acetyltransferase -
JI728_RS00920 (196199) 196199..196486 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
JI728_RS00925 (196474) 196474..196959 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
JI728_RS00930 (197330) 197330..197869 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
JI728_RS00935 (198043) 198043..198255 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JI728_RS00940 (198543) 198543..198833 - 291 WP_000455790.1 HTH-type transcriptional regulator -
JI728_RS00945 (199272) 199272..199982 + 711 WP_000190524.1 DUF3053 domain-containing protein -
JI728_RS00950 (200032) 200032..200994 - 963 WP_000804673.1 glyoxylate/hydroxypyruvate reductase GhrB -
JI728_RS00955 (201213) 201213..201875 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T187153 WP_000533909.1 NZ_CP068386:196474-196959 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T187153 NZ_CP089778:c3120385-3120029 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT187153 WP_000965886.1 NZ_CP068386:196199-196486 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT187153 NZ_CP089778:c3120599-3120369 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References