Detailed information of TA system TA187149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2535318..2535946
• Replicon: chromosome
• Accession: NZ_CP068290
• Organism: Corynebacterium glutamicum strain ATCC 21573

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: JJQ73_RS14815
• Protein ID: WP_258879524.1
• Coordinates: 2535764..2535946 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: JJQ73_RS11700
• Protein ID: WP_220313013.1
• Coordinates: 2535318..2535767 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJQ73_RS11680 (JJQ73_11680)	2531808..2532014	-	207	WP_003857695.1	hypothetical protein	-
JJQ73_RS11685 (JJQ73_11685)	2532033..2532793	-	761	Protein_2295	3-hydroxybutyrate dehydrogenase	-
JJQ73_RS11690 (JJQ73_11690)	2532898..2534013	-	1116	WP_258879523.1	PucR family transcriptional regulator	-
JJQ73_RS11695 (JJQ73_11695)	2534258..2534833	+	576	WP_003857696.1	M23 family metallopeptidase	-
JJQ73_RS11700 (JJQ73_11700)	2535318..2535767	+	450	WP_220313013.1	helix-turn-helix domain-containing protein	Antitoxin
JJQ73_RS14815	2535764..2535946	+	183	WP_258879524.1	PIN domain-containing protein	Toxin
JJQ73_RS11705 (JJQ73_11705)	2535971..2536318	+	348	WP_258879525.1	PIN domain-containing protein	-
JJQ73_RS11715 (JJQ73_11715)	2537018..2537482	+	465	WP_074493748.1	hypothetical protein	-
JJQ73_RS11720 (JJQ73_11720)	2537563..2537919	+	357	WP_003857996.1	DUF3817 domain-containing protein	-
JJQ73_RS11725 (JJQ73_11725)	2537994..2538611	-	618	WP_143855184.1	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase	-
JJQ73_RS11730 (JJQ73_11730)	2538638..2539375	-	738	WP_003857993.1	ribonuclease PH	-
JJQ73_RS11735 (JJQ73_11735)	2539500..2540588	-	1089	WP_258879526.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2532033..2544216	12183
	-	flank	IS/Tn	-	-	2540623..2541234	611

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SinI-like, DNA-binding domain (79-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6910.91 Da
• Isoelectric Point: 4.8291

>T187149 WP_258879524.1 NZ_CP068290:2535764-2535946 [Corynebacterium glutamicum]
VSGFTVVYDANVLYPTMLRDILIRLAGTGIYQARWTEDILDEVFRNLQANRPDLDPSKLR

Nucleotide

• Length: 183 bp

>T187149 NZ_CP089778:c2881292-2880897 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16356.60 Da
• Isoelectric Point: 6.6436

>AT187149 WP_220313013.1 NZ_CP068290:2535318-2535767 [Corynebacterium glutamicum]
MSHLQDNELASTAATACKALQKINRVLSDTSTNKDVKVVVEDSDDVIRLPREVAKVLREILVNSAAGRSVGVIPMRAELT
TQQAANLLNVSRPHVIKLMDDGILPGHKVGTHRRIYAADAQAYKHQRDIDTRTAADDLTALTEEMGLYE

Nucleotide

• Length: 450 bp

>AT187149 NZ_CP089778:c2881534-2881289 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA