Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4604405..4605021 Replicon chromosome
Accession NZ_CP068287
Organism Enterobacter hormaechei strain 1575

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJL14_RS22040 Protein ID WP_080298797.1
Coordinates 4604405..4604776 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag JJL14_RS22045 Protein ID WP_023298920.1
Coordinates 4604779..4605021 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL14_RS22025 4601905..4602807 + 903 WP_063148344.1 formate dehydrogenase subunit beta -
JJL14_RS22030 4602804..4603439 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
JJL14_RS22035 4603436..4604365 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
JJL14_RS22040 4604405..4604776 - 372 WP_080298797.1 type II toxin-antitoxin system VapC family toxin Toxin
JJL14_RS22045 4604779..4605021 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
JJL14_RS22050 4605221..4606141 + 921 WP_063148343.1 alpha/beta hydrolase -
JJL14_RS22055 4606150..4607091 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
JJL14_RS22060 4607136..4607573 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
JJL14_RS22065 4607570..4608451 - 882 WP_023298923.1 virulence factor BrkB family protein -
JJL14_RS22070 4608445..4609044 - 600 WP_023315056.1 glucose-1-phosphatase -
JJL14_RS22075 4609163..4609963 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.66 Da        Isoelectric Point: 6.4865

>T187146 WP_080298797.1 NZ_CP068287:c4604776-4604405 [Enterobacter hormaechei]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T187146 NZ_CP089778:c2865857-2865438 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT187146 WP_023298920.1 NZ_CP068287:c4605021-4604779 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT187146 NZ_CP089778:c2866078-2865854 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References