Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3512431..3513052 Replicon chromosome
Accession NZ_CP068287
Organism Enterobacter hormaechei strain 1575

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag JJL14_RS16895 Protein ID WP_015571250.1
Coordinates 3512834..3513052 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag JJL14_RS16890 Protein ID WP_006809850.1
Coordinates 3512431..3512805 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL14_RS16880 3507559..3508752 + 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JJL14_RS16885 3508775..3511921 + 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
JJL14_RS16890 3512431..3512805 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
JJL14_RS16895 3512834..3513052 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
JJL14_RS16900 3513260..3513811 + 552 WP_023305596.1 maltose O-acetyltransferase -
JJL14_RS16905 3513928..3514395 + 468 WP_022647269.1 hypothetical protein -
JJL14_RS16910 3514367..3515827 - 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
JJL14_RS16915 3515930..3516640 + 711 WP_046620525.1 GNAT family N-acetyltransferase -
JJL14_RS16920 3516637..3516777 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JJL14_RS16925 3516780..3517040 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T187145 WP_015571250.1 NZ_CP068287:3512834-3513052 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T187145 NZ_CP089778:2819481-2819906 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACCGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT187145 WP_006809850.1 NZ_CP068287:3512431-3512805 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT187145 NZ_CP089778:2819254-2819475 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References