Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2288463..2289202 Replicon chromosome
Accession NZ_CP068287
Organism Enterobacter hormaechei strain 1575

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JJL14_RS10820 Protein ID WP_063139083.1
Coordinates 2288717..2289202 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JJL14_RS10815 Protein ID WP_046621516.1
Coordinates 2288463..2288729 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL14_RS10790 2283611..2284135 + 525 WP_087878309.1 fimbrial protein -
JJL14_RS10795 2284159..2285295 + 1137 WP_063147317.1 type 1 fimbrial protein -
JJL14_RS10800 2285416..2285973 + 558 WP_023300131.1 OmpH family outer membrane protein -
JJL14_RS10805 2285952..2287340 - 1389 WP_063147318.1 MFS transporter -
JJL14_RS10810 2287470..2288399 + 930 WP_063147319.1 LysR family transcriptional regulator -
JJL14_RS10815 2288463..2288729 + 267 WP_046621516.1 DUF1778 domain-containing protein Antitoxin
JJL14_RS10820 2288717..2289202 + 486 WP_063139083.1 GNAT family N-acetyltransferase Toxin
JJL14_RS10825 2289228..2289797 - 570 WP_063147320.1 hypothetical protein -
JJL14_RS10830 2289930..2290259 + 330 WP_023306210.1 hypothetical protein -
JJL14_RS10835 2290234..2291037 - 804 WP_063147321.1 DUF4225 domain-containing protein -
JJL14_RS10840 2291688..2292980 - 1293 WP_063147323.1 glycoside hydrolase -
JJL14_RS10845 2293085..2293843 - 759 WP_063147324.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17544.22 Da        Isoelectric Point: 9.6275

>T187143 WP_063139083.1 NZ_CP068287:2288717-2289202 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T187143 NZ_CP089778:c2379726-2379292 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT187143 WP_046621516.1 NZ_CP068287:2288463-2288729 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNNEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT187143 NZ_CP089778:c2379987-2379733 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References