Detailed information of TA system TA187132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2952769..2954386
• Replicon: chromosome
• Accession: NZ_CP068285
• Organism: Ralstonia syzygii subsp. celebesensis strain UGMSS_Db01

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JK151_RS13695
• Protein ID: WP_078222912.1
• Coordinates: 2953040..2954386 (+)
• Length: 449 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JK151_RS13690
• Protein ID: WP_078222913.1
• Coordinates: 2952769..2953035 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK151_RS13660	2948029..2948505	+	477	WP_078222917.1	RidA family protein	-
JK151_RS13665	2948608..2949447	+	840	WP_078222916.1	AraC family transcriptional regulator	-
JK151_RS13670	2949450..2950559	+	1110	WP_078222915.1	peptidase	-
JK151_RS13675	2950586..2950969	-	384	WP_013210318.1	VOC family protein	-
JK151_RS13680	2951209..2951652	+	444	WP_172840169.1	PGDYG domain-containing protein	-
JK151_RS13685	2951668..2952573	-	906	WP_078222914.1	hypothetical protein	-
JK151_RS13690	2952769..2953035	+	267	WP_078222913.1	helix-turn-helix domain-containing protein	Antitoxin
JK151_RS13695	2953040..2954386	+	1347	WP_078222912.1	type II toxin-antitoxin system HipA family toxin	Toxin
JK151_RS13700	2954463..2955359	+	897	WP_078222911.1	DUF2236 domain-containing protein	-
JK151_RS13705	2955363..2956931	-	1569	WP_075467852.1	MFS transporter	-
JK151_RS13710	2957024..2957974	-	951	WP_013210325.1	LysR family transcriptional regulator	-
JK151_RS13715	2958114..2958740	+	627	WP_013210326.1	FMN-dependent NADH-azoreductase	-
JK151_RS13720	2958874..2959086	-	213	WP_201853558.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (11-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 449 a.a.
• Molecular weight: 49831.16 Da
• Isoelectric Point: 7.5915

>T187132 WP_078222912.1 NZ_CP068285:2953040-2954386 [Ralstonia syzygii subsp. celebesensis]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPASIGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDERWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCQPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLVARTPEVIRTVRALLPEDFPQPLADRILRGLQSAADRLAQ

Nucleotide

• Length: 1347 bp

>T187132 NZ_CP089778:1765700-1766104 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9773.30 Da
• Isoelectric Point: 11.3495

>AT187132 WP_078222913.1 NZ_CP068285:2952769-2953035 [Ralstonia syzygii subsp. celebesensis]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELATRMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Nucleotide

• Length: 267 bp

>AT187132 NZ_CP089778:1765491-1765694 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA