Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1389638..1390227 Replicon chromosome
Accession NZ_CP068285
Organism Ralstonia syzygii subsp. celebesensis strain UGMSS_Db01

Toxin (Protein)


Gene name hicA Uniprot ID A0A1U9VH68
Locus tag JK151_RS06525 Protein ID WP_072633588.1
Coordinates 1389973..1390227 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1U9VFS6
Locus tag JK151_RS06520 Protein ID WP_028853154.1
Coordinates 1389638..1389976 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK151_RS06490 1385937..1386275 + 339 WP_078222081.1 phage tail protein -
JK151_RS06495 1386272..1386949 + 678 WP_078222080.1 phage tail protein -
JK151_RS06500 1386955..1387551 + 597 WP_078222079.1 tail fiber assembly protein -
JK151_RS06505 1387548..1388249 + 702 WP_078222078.1 phage minor tail protein L -
JK151_RS06510 1388251..1388962 + 712 Protein_1286 C40 family peptidase -
JK151_RS06515 1388966..1389568 + 603 WP_072633645.1 tail assembly protein -
JK151_RS06520 1389638..1389976 - 339 WP_028853154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JK151_RS06525 1389973..1390227 - 255 WP_072633588.1 type II toxin-antitoxin system HicA family toxin Toxin
JK151_RS06530 1390278..1393433 + 3156 WP_078222077.1 host specificity protein J -
JK151_RS06535 1393770..1394426 + 657 WP_078222075.1 hypothetical protein -
JK151_RS06540 1394495..1394986 + 492 WP_011001641.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1359060..1408621 49561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T187130 WP_072633588.1 NZ_CP068285:c1390227-1389973 [Ralstonia syzygii subsp. celebesensis]
MKAKHQKTLELIFSRPTPAGVKWADAVTLMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T187130 NZ_CP089778:c1574922-1574521 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11968.58 Da        Isoelectric Point: 5.1375

>AT187130 WP_028853154.1 NZ_CP068285:c1389976-1389638 [Ralstonia syzygii subsp. celebesensis]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp

>AT187130 NZ_CP089778:c1575176-1574919 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VH68

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VFS6

References