Detailed information of TA system TA187118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4580451..4581265
• Replicon: chromosome
• Accession: NZ_CP068283
• Organism: Escherichia coli strain CY598

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: JI738_RS22360
• Protein ID: WP_001054376.1
• Coordinates: 4581008..4581265 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: JI738_RS22355
• Protein ID: WP_001309181.1
• Coordinates: 4580451..4580996 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JI738_RS22325 (4576142)	4576142..4577455	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
JI738_RS22330 (4577467)	4577467..4577745	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
JI738_RS22335 (4577742)	4577742..4578863	-	1122	WP_000010829.1	M42 family metallopeptidase	-
JI738_RS22340 (4579108)	4579108..4579224	-	117	Protein_4364	VOC family protein	-
JI738_RS22345 (4579262)	4579262..4579480	-	219	Protein_4365	hypothetical protein	-
JI738_RS22350 (4579649)	4579649..4580395	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
JI738_RS22355 (4580451)	4580451..4580996	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
JI738_RS22360 (4581008)	4581008..4581265	-	258	WP_001054376.1	YjhX family toxin	Toxin
JI738_RS23400 (4581756)	4581756..4581887	-	132	WP_001309182.1	hypothetical protein	-
JI738_RS22370 (4582003)	4582003..4583243	+	1241	Protein_4370	helicase YjhR	-
JI738_RS23405 (4583511)	4583511..4583716	-	206	Protein_4371	HNH endonuclease	-
JI738_RS22375 (4583826)	4583826..4584806	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
JI738_RS22380 (4584871)	4584871..4585977	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T187118 WP_001054376.1 NZ_CP068283:c4581265-4581008 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187118 NZ_CP089778:c755029-754646 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT187118 WP_001309181.1 NZ_CP068283:c4580996-4580451 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT187118 NZ_CP089778:c755279-755124 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8