Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2144832..2145663 Replicon chromosome
Accession NZ_CP068283
Organism Escherichia coli strain CY598

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JI738_RS10780 Protein ID WP_000854814.1
Coordinates 2145289..2145663 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag JI738_RS10775 Protein ID WP_001285584.1
Coordinates 2144832..2145200 (+) Length 123 a.a.

Genomic Context

JI738_RS10760JI738_RS10765JI738_RS10770JI738_RS10775JI738_RS10780JI738_RS10785JI738_RS10790JI738_RS10800JI738_RS10795JI738_RS10805JI738_RS10810JI738_RS10815JI738_RS10820
Location: 2142499..2144031 (1533 bp)
Type: Others
Protein ID: WP_001350525.1
Location: 2144028..2144474 (447 bp)
Type: Others
Protein ID: WP_000187523.1
Location: 2144537..2144758 (222 bp)
Type: Others
Protein ID: WP_000692323.1
Location: 2144832..2145200 (369 bp)
Type: Antitoxin
Protein ID: WP_001285584.1
Location: 2145289..2145663 (375 bp)
Type: Toxin
Protein ID: WP_000854814.1
Location: 2145660..2145854 (195 bp)
Type: Others
Protein ID: WP_000988600.1
Location: 2145900..2145980 (81 bp)
Type: Others
Protein ID: Protein_2117
Location: 2146517..2146651 (135 bp)
Type: Others
Protein ID: WP_001297944.1
Location: 2146269..2146397 (129 bp)
Type: Others
Protein ID: Protein_2118
Location: 2146752..2147081 (330 bp)
Type: Others
Protein ID: WP_000450409.1
Location: 2147253..2148311 (1059 bp)
Type: Others
Protein ID: WP_001200891.1
Location: 2148509..2148982 (474 bp)
Type: Others
Protein ID: WP_001105415.1
Location: 2149101..2150267 (1167 bp)
Type: Others
Protein ID: WP_000830156.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JI738_RS10760 (2142499)2142499..2144031+1533WP_001350525.1protein YeeR-
JI738_RS10765 (2144028)2144028..2144474+447WP_000187523.1RadC family protein-
JI738_RS10770 (2144537)2144537..2144758+222WP_000692323.1DUF987 domain-containing protein-
JI738_RS10775 (2144832)2144832..2145200+369WP_001285584.1type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeAAntitoxin
JI738_RS10780 (2145289)2145289..2145663+375WP_000854814.1type IV toxin-antitoxin system cytoskeleton-binding toxin CbtAToxin
JI738_RS10785 (2145660)2145660..2145854+195WP_000988600.1DUF5983 family protein-
JI738_RS10790 (2145900)2145900..2145980+81Protein_2117hypothetical protein-
JI738_RS10795 (2146269)2146269..2146397-129Protein_2118transposase domain-containing protein-
JI738_RS10800 (2146517)2146517..2146651+135WP_001297944.1EutP/PduV family microcompartment system protein-
JI738_RS10805 (2146752)2146752..2147081-330WP_000450409.1DUF496 family protein-
JI738_RS10810 (2147253)2147253..2148311-1059WP_001200891.1FUSC family protein-
JI738_RS10815 (2148509)2148509..2148982-474WP_001105415.1DNA gyrase inhibitor SbmC-
JI738_RS10820 (2149101)2149101..2150267-1167WP_000830156.1serine-type D-Ala-D-Ala carboxypeptidase DacD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T187105 WP_000854814.1 NZ_CP068283:2145289-2145663 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T187105 NZ_CP089778:71807-72208 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT187105 WP_001285584.1 NZ_CP068283:2144832-2145200 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT187105 NZ_CP089778:71575-71814 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829FY50

Antitoxin

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Source
ID
Structure
PDB2H28
AlphaFold DBA0A1M2E8G6

References