187072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4279042..4279696 Replicon chromosome
Accession NZ_CP068281
Organism Escherichia coli strain CY706

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag JJW04_RS20825 Protein ID WP_000244777.1
Coordinates 4279042..4279449 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JJW04_RS20830 Protein ID WP_000354046.1
Coordinates 4279430..4279696 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW04_RS20805 (4274999) 4274999..4276732 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
JJW04_RS20810 (4276738) 4276738..4277448 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJW04_RS20815 (4277473) 4277473..4278369 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JJW04_RS20820 (4278481) 4278481..4279002 + 522 WP_001055874.1 flavodoxin FldB -
JJW04_RS20825 (4279042) 4279042..4279449 - 408 WP_000244777.1 protein YgfX Toxin
JJW04_RS20830 (4279430) 4279430..4279696 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JJW04_RS20835 (4279939) 4279939..4280919 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JJW04_RS20840 (4281115) 4281115..4281774 - 660 WP_000250274.1 hemolysin III family protein -
JJW04_RS20845 (4281938) 4281938..4282249 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JJW04_RS20850 (4282294) 4282294..4283727 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
JJW04_RS20855 (4283784) 4283784..4284527 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T187072 WP_000244777.1 NZ_CP068281:c4279449-4279042 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T187072 NZ_CP089777:1690266-1690583 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT187072 WP_000354046.1 NZ_CP068281:c4279696-4279430 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187072 NZ_CP089777:1689967-1690269 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References