Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2793590..2794116 | Replicon | chromosome |
| Accession | NZ_CP068279 | ||
| Organism | Escherichia coli strain CY708 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | JJW05_RS13600 | Protein ID | WP_000323025.1 |
| Coordinates | 2793590..2793877 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | JJW05_RS13605 | Protein ID | WP_000534858.1 |
| Coordinates | 2793877..2794116 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJW05_RS13550 (2788614) | 2788614..2788829 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| JJW05_RS13555 (2789049) | 2789049..2789219 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| JJW05_RS13560 (2789583) | 2789583..2789798 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| JJW05_RS13565 (2790099) | 2790099..2790311 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| JJW05_RS13570 (2790366) | 2790366..2790455 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| JJW05_RS13575 (2790733) | 2790733..2791485 | - | 753 | WP_001047135.1 | antitermination protein | - |
| JJW05_RS13580 (2791499) | 2791499..2792548 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| JJW05_RS13585 (2792550) | 2792550..2792828 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| JJW05_RS13590 (2792895) | 2792895..2793146 | - | 252 | WP_000980994.1 | protein Rem | - |
| JJW05_RS13595 (2793363) | 2793363..2793518 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| JJW05_RS13600 (2793590) | 2793590..2793877 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| JJW05_RS13605 (2793877) | 2793877..2794116 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| JJW05_RS13610 (2794141) | 2794141..2794446 | + | 306 | WP_001326990.1 | protein YdfV | - |
| JJW05_RS13615 (2794649) | 2794649..2794981 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| JJW05_RS13620 (2795418) | 2795418..2795567 | - | 150 | WP_011443592.1 | protein YdfW | - |
| JJW05_RS13625 (2795602) | 2795602..2795880 | - | 279 | Protein_2663 | hypothetical protein | - |
| JJW05_RS13630 (2795864) | 2795864..2796094 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| JJW05_RS13635 (2796178) | 2796178..2796585 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| JJW05_RS13640 (2796752) | 2796752..2796907 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| JJW05_RS22980 (2796909) | 2796909..2797037 | + | 129 | WP_000344964.1 | protein YdfB | - |
| JJW05_RS13645 (2797067) | 2797067..2797285 | + | 219 | WP_001171942.1 | protein YdfC | - |
| JJW05_RS13650 (2797853) | 2797853..2798041 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| JJW05_RS13655 (2798038) | 2798038..2798229 | + | 192 | WP_001083297.1 | lysis protein YdfD | - |
| JJW05_RS13660 (2798322) | 2798322..2799089 | + | 768 | Protein_2671 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2763048..2807450 | 44402 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T187011 WP_000323025.1 NZ_CP068279:c2793877-2793590 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T187011 NZ_CP089776:c1396643-1396350 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT187011 WP_000534858.1 NZ_CP068279:c2794116-2793877 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT187011 NZ_CP089776:c1396909-1396640 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|