Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2657530..2658168 Replicon chromosome
Accession NZ_CP068279
Organism Escherichia coli strain CY708

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JJW05_RS12920 Protein ID WP_000813794.1
Coordinates 2657530..2657706 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JJW05_RS12925 Protein ID WP_001270286.1
Coordinates 2657752..2658168 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW05_RS12900 (2653149) 2653149..2654363 - 1215 WP_001326689.1 BenE family transporter YdcO -
JJW05_RS12905 (2654416) 2654416..2654952 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JJW05_RS12910 (2655025) 2655025..2656986 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JJW05_RS12915 (2657078) 2657078..2657308 - 231 WP_000494244.1 YncJ family protein -
JJW05_RS12920 (2657530) 2657530..2657706 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JJW05_RS12925 (2657752) 2657752..2658168 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JJW05_RS12930 (2658247) 2658247..2659653 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JJW05_RS12935 (2659898) 2659898..2661043 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JJW05_RS12940 (2661061) 2661061..2662074 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JJW05_RS12945 (2662075) 2662075..2663016 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T187009 WP_000813794.1 NZ_CP068279:2657530-2657706 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T187009 NZ_CP089776:1247533-1247907 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT187009 WP_001270286.1 NZ_CP068279:2657752-2658168 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT187009 NZ_CP089776:1247339-1247536 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References