Detailed information of TA system TA186989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 99386..99903
• Replicon: chromosome
• Accession: NZ_CP068278
• Organism: Corynebacterium aquatimens strain CNCTC

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JKI95_RS00515
• Protein ID: WP_234948941.1
• Coordinates: 99386..99646 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JKI95_RS00520
• Protein ID: WP_234948940.1
• Coordinates: 99640..99903 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKI95_RS00485 (JKI95_00470)	94562..94981	+	420	WP_284522919.1	metal-sulfur cluster assembly factor	-
JKI95_RS00490 (JKI95_00475)	95015..96640	+	1626	Protein_97	ABC-F family ATP-binding cassette domain-containing protein	-
JKI95_RS00495 (JKI95_00480)	96640..97188	+	549	WP_234948945.1	DUF421 domain-containing protein	-
JKI95_RS00500 (JKI95_00485)	97185..97958	-	774	WP_284522920.1	hypothetical protein	-
JKI95_RS00505 (JKI95_00490)	98340..99077	-	738	WP_234948943.1	glutamine amidotransferase	-
JKI95_RS00510 (JKI95_00495)	99134..99379	+	246	WP_234948942.1	PLDc N-terminal domain-containing protein	-
JKI95_RS00515 (JKI95_00500)	99386..99646	-	261	WP_234948941.1	Txe/YoeB family addiction module toxin	Toxin
JKI95_RS00520 (JKI95_00505)	99640..99903	-	264	WP_234948940.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JKI95_RS00525 (JKI95_00510)	99975..101344	-	1370	Protein_104	PFL family protein	-
JKI95_RS00530 (JKI95_00515)	101357..101638	-	282	WP_234948938.1	ACT domain-containing protein	-
JKI95_RS00535 (JKI95_00520)	101676..102179	+	504	WP_284522921.1	hypothetical protein	-
JKI95_RS00540 (JKI95_00525)	102199..102873	+	675	WP_234948936.1	NAD(P)H-binding protein	-
JKI95_RS00545	102940..103149	-	210	WP_284522922.1	hypothetical protein	-
JKI95_RS00550 (JKI95_00530)	103185..103673	-	489	WP_284522923.1	glutamine amidotransferase	-
JKI95_RS00555 (JKI95_00535)	103684..104261	-	578	Protein_110	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10359.75 Da
• Isoelectric Point: 8.4870

>T186989 WP_234948941.1 NZ_CP068278:c99646-99386 [Corynebacterium aquatimens]
VLVRWERDAWEEYCRRQIEDRRILKRINTLITDVLRNGNEGIGKPEPLKHDFSGYWSRRINSEHRLIYKIDDGGITIVAC
RYHYGE

Nucleotide

• Length: 261 bp

>T186989 NZ_CP089776:368020-368322 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9901.21 Da
• Isoelectric Point: 4.4755

>AT186989 WP_234948940.1 NZ_CP068278:c99903-99640 [Corynebacterium aquatimens]
VRIMSYTESRAKYADMLTSVVDDCEEVIITRAGHEPVVVVSLAEYESLKETAYLLRSPANARMLKERIARVERGQAEEHE
LIEDDTC

Nucleotide

• Length: 264 bp

>AT186989 NZ_CP089776:367796-368023 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA