Detailed information of TA system TA186988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1632458..1634094
• Replicon: chromosome
• Accession: NZ_CP068253
• Organism: Acinetobacter junii strain CAM121

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: ABCA12_RS07900
• Protein ID: WP_201898205.1
• Coordinates: 1632763..1634094 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: ABCA12_RS07895
• Protein ID: WP_004954417.1
• Coordinates: 1632458..1632766 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABCA12_RS07870	1628178..1629439	-	1262	Protein_1525	LlaJI family restriction endonuclease	-
ABCA12_RS07875	1629459..1629788	-	330	WP_201898204.1	hypothetical protein	-
ABCA12_RS07885	1631008..1631592	-	585	Protein_1528	AAA family ATPase	-
ABCA12_RS07890	1632137..1632388	+	252	WP_125298717.1	VF530 family protein	-
ABCA12_RS07895	1632458..1632766	-	309	WP_004954417.1	helix-turn-helix domain-containing protein	Antitoxin
ABCA12_RS07900	1632763..1634094	-	1332	WP_201898205.1	HipA domain-containing protein	Toxin
ABCA12_RS07905	1634372..1635070	+	699	WP_201898206.1	DUF1826 domain-containing protein	-
ABCA12_RS07910	1635130..1635927	-	798	WP_201898207.1	sulfite exporter TauE/SafE family protein	-
ABCA12_RS07915	1635969..1636462	-	494	Protein_1534	flavin reductase	-
ABCA12_RS07920	1636649..1637677	-	1029	WP_201898208.1	methionine synthase	-
ABCA12_RS07925	1637701..1638696	-	996	WP_201898209.1	DUF1852 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-365)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50694.37 Da
• Isoelectric Point: 4.9024

>T186988 WP_201898205.1 NZ_CP068253:c1634094-1632763 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYDLEYAIHNLDKRDEHACSLSLPIQILIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWNNQKWHRYGLESVYSILNKASGSHLNHFEVIENLCNLLISIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPLYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSLSTLK
SLASHLVGLKQRLIDKGVPKQIVEMPALSFDYVEAKLERWELL

Nucleotide

• Length: 1332 bp

>T186988 NZ_CP089776:71856-72257 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11692.65 Da
• Isoelectric Point: 9.9970

>AT186988 WP_004954417.1 NZ_CP068253:c1632766-1632458 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Nucleotide

• Length: 309 bp

>AT186988 NZ_CP089776:71624-71863 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA