Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 157731..158319 | Replicon | chromosome |
| Accession | NZ_CP068253 | ||
| Organism | Acinetobacter junii strain CAM121 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | N8XIV8 |
| Locus tag | ABCA12_RS00720 | Protein ID | WP_004797784.1 |
| Coordinates | 157731..158018 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | - |
| Locus tag | ABCA12_RS00725 | Protein ID | WP_201897946.1 |
| Coordinates | 158005..158319 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ABCA12_RS00690 | 153212..153649 | + | 438 | WP_004964971.1 | DUF2147 domain-containing protein | - |
| ABCA12_RS00695 | 153711..154061 | - | 351 | WP_039047790.1 | arsenate reductase | - |
| ABCA12_RS00700 | 154546..155370 | - | 825 | WP_151974385.1 | exodeoxyribonuclease III | - |
| ABCA12_RS00705 | 155410..156060 | + | 651 | WP_151974387.1 | orotate phosphoribosyltransferase | - |
| ABCA12_RS00710 | 156343..156549 | - | 207 | Protein_136 | four-helix bundle copper-binding protein | - |
| ABCA12_RS00715 | 156591..157520 | + | 930 | WP_057692912.1 | IS5 family transposase | - |
| ABCA12_RS00720 | 157731..158018 | + | 288 | WP_004797784.1 | BrnT family toxin | Toxin |
| ABCA12_RS00725 | 158005..158319 | + | 315 | WP_201897946.1 | BrnA antitoxin family protein | Antitoxin |
| ABCA12_RS00730 | 158403..158738 | + | 336 | WP_151974389.1 | hypothetical protein | - |
| ABCA12_RS00735 | 158788..158967 | + | 180 | WP_004679044.1 | hypothetical protein | - |
| ABCA12_RS00740 | 158964..159350 | + | 387 | WP_151974391.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| ABCA12_RS00745 | 159352..159912 | - | 561 | WP_151974393.1 | macro domain-containing protein | - |
| ABCA12_RS00750 | 159966..160481 | + | 516 | WP_002125020.1 | hypothetical protein | - |
| ABCA12_RS00755 | 160502..160690 | - | 189 | WP_005328396.1 | DUF3565 domain-containing protein | - |
| ABCA12_RS00760 | 160691..161143 | - | 453 | WP_005328393.1 | MarR family transcriptional regulator | - |
| ABCA12_RS00765 | 161326..161805 | + | 480 | WP_004769961.1 | glutathione peroxidase | - |
| ABCA12_RS00770 | 162021..162965 | + | 945 | WP_004756907.1 | glutathione synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 156591..157520 | 929 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11263.65 Da Isoelectric Point: 5.2134
>T186987 WP_004797784.1 NZ_CP068253:157731-158018 [Acinetobacter junii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFDDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERDKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFDDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERDKYEHG
Download Length: 288 bp
>T186987 NZ_CP089775:3828041-3828451 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12227.84 Da Isoelectric Point: 7.2029
>AT186987 WP_201897946.1 NZ_CP068253:158005-158319 [Acinetobacter junii]
MSMVRYSRKELNEKFSDKQDAEIERLLAKGTVADDQLDLSDIPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSRKELNEKFSDKQDAEIERLLAKGTVADDQLDLSDIPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT186987 NZ_CP089775:3827766-3828044 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|