186965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 2636884..2637466 Replicon chromosome
Accession NZ_CP068249
Organism Enterococcus faecalis strain T90-1

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag JG557_RS13070 Protein ID WP_002355414.1
Coordinates 2636884..2637192 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag JG557_RS13075 Protein ID WP_002326825.1
Coordinates 2637194..2637466 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG557_RS13040 2632670..2633602 - 933 WP_002363040.1 tagatose-6-phosphate kinase -
JG557_RS13045 2633613..2634128 - 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
JG557_RS13050 2634145..2634570 - 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
JG557_RS13055 2635059..2635826 + 768 WP_002384821.1 DeoR/GlpR family DNA-binding transcription regulator -
JG557_RS13060 2635831..2636331 + 501 WP_002355415.1 HAD family hydrolase -
JG557_RS13065 2636376..2636804 + 429 WP_071623404.1 tyrosine-type recombinase/integrase -
JG557_RS13070 2636884..2637192 - 309 WP_002355414.1 zeta toxin family protein Toxin
JG557_RS13075 2637194..2637466 - 273 WP_002326825.1 antitoxin Antitoxin
JG557_RS13080 2637483..2637698 - 216 WP_002364919.1 peptide-binding protein -
JG557_RS13085 2637769..2638623 - 855 WP_002364921.1 ParA family protein -
JG557_RS13090 2638731..2639893 + 1163 WP_127824108.1 IS3 family transposase -
JG557_RS13095 2640109..2641573 - 1465 Protein_2552 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
JG557_RS13100 2641563..2641829 - 267 WP_002384819.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T186965 WP_002355414.1 NZ_CP068249:c2637192-2636884 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T186965 NZ_CP089775:2260190-2260588 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT186965 WP_002326825.1 NZ_CP068249:c2637466-2637194 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT186965 NZ_CP089775:2259962-2260189 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References