Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1533408..1533922 Replicon chromosome
Accession NZ_CP068247
Organism Staphylococcus sp. T93

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JG553_RS07545 Protein ID WP_000581792.1
Coordinates 1533408..1533617 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JG553_RS07550 Protein ID WP_000138932.1
Coordinates 1533629..1533922 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG553_RS07525 1528916..1530274 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JG553_RS07530 1530289..1531359 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JG553_RS07535 1531677..1532879 + 1203 WP_001109939.1 rod shape-determining protein RodA -
JG553_RS07540 1533143..1533280 - 138 WP_000828354.1 hypothetical protein -
JG553_RS07545 1533408..1533617 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
JG553_RS07550 1533629..1533922 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JG553_RS07555 1534088..1535572 + 1485 WP_000571549.1 cardiolipin synthase -
JG553_RS07560 1535600..1536247 + 648 WP_001187629.1 HD domain-containing protein -
JG553_RS07565 1537060..1537932 - 873 WP_000725802.1 membrane protein insertase YidC -
JG553_RS07570 1538018..1538659 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T186956 WP_000581792.1 NZ_CP068247:c1533617-1533408 [Staphylococcus sp. T93]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T186956 NZ_CP089775:1769376-1769780 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT186956 WP_000138932.1 NZ_CP068247:c1533922-1533629 [Staphylococcus sp. T93]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT186956 NZ_CP089775:1769167-1769370 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References