Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 314271..314748 Replicon chromosome
Accession NZ_CP068247
Organism Staphylococcus sp. T93

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag JG553_RS01515 Protein ID WP_000052078.1
Coordinates 314271..314459 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JG553_RS01520 Protein ID WP_001059690.1
Coordinates 314488..314748 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG553_RS01485 310312..310782 + 471 WP_000824472.1 hypothetical protein -
JG553_RS01490 311123..311809 + 687 WP_001548082.1 thermonuclease family protein -
JG553_RS01495 312166..312366 + 201 WP_001059082.1 cold-shock protein -
JG553_RS01500 312862..313080 - 219 WP_000005886.1 hypothetical protein -
JG553_RS01505 313142..313426 - 285 WP_001004395.1 hypothetical protein -
JG553_RS01510 313514..314083 - 570 WP_001106654.1 hypothetical protein -
JG553_RS01515 314271..314459 - 189 WP_000052078.1 hypothetical protein Toxin
JG553_RS01520 314488..314748 - 261 WP_001059690.1 hypothetical protein Antitoxin
JG553_RS01525 315089..315292 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JG553_RS01530 315289..315525 - 237 WP_000368687.1 hypothetical protein -
JG553_RS01535 315750..316331 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
JG553_RS01540 316404..317021 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JG553_RS01545 317176..317670 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JG553_RS01550 318069..318491 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JG553_RS01555 318639..319355 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T186951 WP_000052078.1 NZ_CP068247:c314459-314271 [Staphylococcus sp. T93]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T186951 NZ_CP089775:1391330-1391761 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT186951 WP_001059690.1 NZ_CP068247:c314748-314488 [Staphylococcus sp. T93]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT186951 NZ_CP089775:1391073-1391333 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References