Detailed information of TA system TA186943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3630329..3631550
• Replicon: chromosome
• Accession: NZ_CP068239
• Organism: Pseudomonas aeruginosa strain PA19-3047

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: V6AG16
• Locus tag: JJQ57_RS17120
• Protein ID: WP_003088107.1
• Coordinates: 3630972..3631550 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JJQ57_RS17115
• Protein ID: WP_003088112.1
• Coordinates: 3630329..3630883 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJQ57_RS17090	3625897..3626448	+	552	WP_023098678.1	XRE family transcriptional regulator	-
JJQ57_RS17095	3626445..3626843	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
JJQ57_RS17100	3626856..3627179	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
JJQ57_RS17105	3627510..3627971	+	462	WP_003088117.1	(2Fe-2S)-binding protein	-
JJQ57_RS17110	3627976..3630171	+	2196	WP_003088114.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JJQ57_RS17115	3630329..3630883	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
JJQ57_RS17120	3630972..3631550	+	579	WP_003088107.1	HD domain-containing protein	Toxin
JJQ57_RS17125	3631659..3632846	-	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JJQ57_RS17130	3632836..3635007	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
JJQ57_RS17135	3634997..3636274	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21885.74 Da
• Isoelectric Point: 5.3655

>T186943 WP_003088107.1 NZ_CP068239:3630972-3631550 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T186943 NZ_CP089775:c760455-760147 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT186943 WP_003088112.1 NZ_CP068239:3630329-3630883 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT186943 NZ_CP089775:c760687-760442 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: V6AG16