Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147334..147839 Replicon chromosome
Accession NZ_CP068239
Organism Pseudomonas aeruginosa strain PA19-3047

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag JJQ57_RS00655 Protein ID WP_003083773.1
Coordinates 147334..147615 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag JJQ57_RS00660 Protein ID WP_003083775.1
Coordinates 147612..147839 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ57_RS00630 142585..143934 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
JJQ57_RS00635 143983..144669 + 687 WP_003083762.1 FadR family transcriptional regulator -
JJQ57_RS00640 144770..145504 + 735 WP_003083764.1 GntR family transcriptional regulator -
JJQ57_RS00645 145708..146094 + 387 WP_003083767.1 aegerolysin family protein -
JJQ57_RS00650 146126..147034 - 909 WP_003083769.1 LysR family transcriptional regulator -
JJQ57_RS00655 147334..147615 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
JJQ57_RS00660 147612..147839 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
JJQ57_RS00665 148015..148635 - 621 WP_003101226.1 hypothetical protein -
JJQ57_RS00670 148736..149236 + 501 WP_003083778.1 LEA type 2 family protein -
JJQ57_RS00675 149309..149650 + 342 WP_014603467.1 alkylphosphonate utilization protein -
JJQ57_RS00680 149732..151159 - 1428 WP_003083784.1 GABA permease -
JJQ57_RS00685 151328..152821 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T186940 WP_003083773.1 NZ_CP068239:c147615-147334 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T186940 NZ_CP089775:721593-721988 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT186940 WP_003083775.1 NZ_CP068239:c147839-147612 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT186940 NZ_CP089775:721339-721593 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References