Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4349840..4351100 Replicon chromosome
Accession NZ_CP068238
Organism Pseudomonas aeruginosa strain A39-1

Toxin (Protein)


Gene name - Uniprot ID A0A424XGP4
Locus tag JHW37_RS20390 Protein ID WP_074197528.1
Coordinates 4349840..4350595 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2R3IR82
Locus tag JHW37_RS20395 Protein ID WP_003157715.1
Coordinates 4350732..4351100 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW37_RS20380 4347153..4347704 + 552 WP_012076759.1 AAA family ATPase -
JHW37_RS20385 4347708..4349069 - 1362 WP_079383456.1 DNA recombination protein RmuC -
JHW37_RS20390 4349840..4350595 - 756 WP_074197528.1 RES family NAD+ phosphorylase Toxin
JHW37_RS20395 4350732..4351100 - 369 WP_003157715.1 DUF2384 domain-containing protein Antitoxin
JHW37_RS20400 4351174..4352460 - 1287 WP_053814335.1 FAD-binding oxidoreductase -
JHW37_RS20405 4352524..4354017 - 1494 WP_043099249.1 aldehyde dehydrogenase family protein -
JHW37_RS20410 4354191..4354667 + 477 WP_033998987.1 elongation factor GreAB -
JHW37_RS20415 4354670..4354951 - 282 WP_043099250.1 zinc ribbon domain-containing protein -
JHW37_RS20420 4355105..4356091 - 987 WP_079384943.1 nitronate monooxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-205)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28325.53 Da        Isoelectric Point: 8.3280

>T186938 WP_074197528.1 NZ_CP068238:c4350595-4349840 [Pseudomonas aeruginosa]
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA

Download         Length: 756 bp

>T186938 NZ_CP089775:708415-708816 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13353.60 Da        Isoelectric Point: 9.9874

>AT186938 WP_003157715.1 NZ_CP068238:c4351100-4350732 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT186938 NZ_CP089775:708173-708418 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A424XGP4

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3IR82

References