Detailed information of TA system TA186937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3428847..3430068
• Replicon: chromosome
• Accession: NZ_CP068238
• Organism: Pseudomonas aeruginosa strain A39-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3S0L3G0
• Locus tag: JHW37_RS16095
• Protein ID: WP_003153547.1
• Coordinates: 3429490..3430068 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JHW37_RS16090
• Protein ID: WP_053817333.1
• Coordinates: 3428847..3429401 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW37_RS16065	3424416..3424967	+	552	WP_043101666.1	XRE family transcriptional regulator	-
JHW37_RS16070	3424964..3425362	-	399	WP_033997206.1	NADH-quinone oxidoreductase subunit A	-
JHW37_RS16075	3425375..3425698	-	324	WP_012076113.1	quaternary ammonium compound efflux SMR transporter SugE	-
JHW37_RS16080	3426028..3426489	+	462	WP_034082656.1	(2Fe-2S)-binding protein	-
JHW37_RS16085	3426494..3428689	+	2196	WP_053817332.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JHW37_RS16090	3428847..3429401	+	555	WP_053817333.1	helix-turn-helix domain-containing protein	Antitoxin
JHW37_RS16095	3429490..3430068	+	579	WP_003153547.1	HD domain-containing protein	Toxin
JHW37_RS16100	3430177..3431364	-	1188	WP_012076116.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JHW37_RS16105	3431354..3433525	-	2172	WP_043104503.1	type I secretion system permease/ATPase	-
JHW37_RS16110	3433515..3434792	-	1278	WP_003153546.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-172)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21852.75 Da
• Isoelectric Point: 5.6237

>T186937 WP_003153547.1 NZ_CP068238:3429490-3430068 [Pseudomonas aeruginosa]
MSLELLKNRLDFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T186937 NZ_CP089775:c702496-702083 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20369.44 Da
• Isoelectric Point: 8.9546

>AT186937 WP_053817333.1 NZ_CP068238:3428847-3429401 [Pseudomonas aeruginosa]
MTESLPSSSLGPALRRWRLLHRVKQAHAAELFGVAQSTISRWESGAQALRAEERTRLETLLGARLETAADRALARLVDGS
PQPMHLICDLTHRLLACSPARAAQFAVPLGDLLGRSLWPYCSEEILRQEAALDDLGWRELLAPPALEFASGTNASTIVPI
RRSRCRWTRLTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT186937 NZ_CP089775:c702729-702493 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Toxin

• AlphaFold DB: A0A3S0L3G0