Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 136571..137076 Replicon chromosome
Accession NZ_CP068238
Organism Pseudomonas aeruginosa strain A39-1

Toxin (Protein)


Gene name parE Uniprot ID A0A3S0LZE8
Locus tag JHW37_RS00625 Protein ID WP_003156094.1
Coordinates 136571..136852 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4P0TKN5
Locus tag JHW37_RS00630 Protein ID WP_034081045.1
Coordinates 136849..137076 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW37_RS00600 131830..133179 + 1350 WP_023443219.1 C4-dicarboxylate transporter DctA -
JHW37_RS00605 133227..133913 + 687 WP_011979163.1 FadR family transcriptional regulator -
JHW37_RS00610 134014..134748 + 735 WP_011979164.1 GntR family transcriptional regulator -
JHW37_RS00615 134915..135315 + 401 Protein_122 hemolysin -
JHW37_RS00620 135383..136273 - 891 WP_043099741.1 LysR family transcriptional regulator -
JHW37_RS00625 136571..136852 - 282 WP_003156094.1 type II toxin-antitoxin system toxin ParE Toxin
JHW37_RS00630 136849..137076 - 228 WP_034081045.1 CopG family ribbon-helix-helix protein Antitoxin
JHW37_RS00635 137252..137872 - 621 WP_053816478.1 hypothetical protein -
JHW37_RS00640 137973..138473 + 501 WP_034081042.1 LEA type 2 family protein -
JHW37_RS00645 138546..138887 + 342 WP_003101229.1 alkylphosphonate utilization protein -
JHW37_RS00650 139007..140434 - 1428 WP_053816479.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10433.15 Da        Isoelectric Point: 9.6558

>T186934 WP_003156094.1 NZ_CP068238:c136852-136571 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T186934 NZ_CP089775:c645565-645152 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT186934 WP_034081045.1 NZ_CP068238:c137076-136849 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ

Download         Length: 228 bp

>AT186934 NZ_CP089775:c645828-645562 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0LZE8

Antitoxin

Source ID Structure
AlphaFold DB A0A4P0TKN5

References