Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 136571..137076 | Replicon | chromosome |
Accession | NZ_CP068238 | ||
Organism | Pseudomonas aeruginosa strain A39-1 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A3S0LZE8 |
Locus tag | JHW37_RS00625 | Protein ID | WP_003156094.1 |
Coordinates | 136571..136852 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A4P0TKN5 |
Locus tag | JHW37_RS00630 | Protein ID | WP_034081045.1 |
Coordinates | 136849..137076 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JHW37_RS00600 | 131830..133179 | + | 1350 | WP_023443219.1 | C4-dicarboxylate transporter DctA | - |
JHW37_RS00605 | 133227..133913 | + | 687 | WP_011979163.1 | FadR family transcriptional regulator | - |
JHW37_RS00610 | 134014..134748 | + | 735 | WP_011979164.1 | GntR family transcriptional regulator | - |
JHW37_RS00615 | 134915..135315 | + | 401 | Protein_122 | hemolysin | - |
JHW37_RS00620 | 135383..136273 | - | 891 | WP_043099741.1 | LysR family transcriptional regulator | - |
JHW37_RS00625 | 136571..136852 | - | 282 | WP_003156094.1 | type II toxin-antitoxin system toxin ParE | Toxin |
JHW37_RS00630 | 136849..137076 | - | 228 | WP_034081045.1 | CopG family ribbon-helix-helix protein | Antitoxin |
JHW37_RS00635 | 137252..137872 | - | 621 | WP_053816478.1 | hypothetical protein | - |
JHW37_RS00640 | 137973..138473 | + | 501 | WP_034081042.1 | LEA type 2 family protein | - |
JHW37_RS00645 | 138546..138887 | + | 342 | WP_003101229.1 | alkylphosphonate utilization protein | - |
JHW37_RS00650 | 139007..140434 | - | 1428 | WP_053816479.1 | GABA permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10433.15 Da Isoelectric Point: 9.6558
>T186934 WP_003156094.1 NZ_CP068238:c136852-136571 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T186934 NZ_CP089775:c645565-645152 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8568.64 Da Isoelectric Point: 5.5740
>AT186934 WP_034081045.1 NZ_CP068238:c137076-136849 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ
Download Length: 228 bp
>AT186934 NZ_CP089775:c645828-645562 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S0LZE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P0TKN5 |