Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4119246..4119865 Replicon chromosome
Accession NZ_CP068237
Organism Klebsiella quasipneumoniae strain YDKL-002

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JJQ56_RS19890 Protein ID WP_002892050.1
Coordinates 4119647..4119865 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JJQ56_RS19885 Protein ID WP_002892066.1
Coordinates 4119246..4119620 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ56_RS19875 4114399..4115592 + 1194 WP_153679580.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JJQ56_RS19880 4115615..4118761 + 3147 WP_153679579.1 multidrug efflux RND transporter permease subunit AcrB -
JJQ56_RS19885 4119246..4119620 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JJQ56_RS19890 4119647..4119865 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JJQ56_RS19895 4120024..4120590 + 567 WP_202023910.1 maltose O-acetyltransferase -
JJQ56_RS19900 4120562..4120693 - 132 WP_202023911.1 hypothetical protein -
JJQ56_RS19905 4120727..4121197 + 471 WP_153679577.1 hypothetical protein -
JJQ56_RS19910 4121166..4122623 - 1458 WP_202023912.1 PLP-dependent aminotransferase family protein -
JJQ56_RS19915 4122724..4123422 + 699 WP_202023913.1 GNAT family N-acetyltransferase -
JJQ56_RS19920 4123419..4123559 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JJQ56_RS19925 4123559..4123822 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T186932 WP_002892050.1 NZ_CP068237:4119647-4119865 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T186932 NZ_CP089775:367659-368084 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT186932 WP_002892066.1 NZ_CP068237:4119246-4119620 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT186932 NZ_CP089775:367441-367662 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References