Detailed information of TA system TA186929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2717470..2719058
• Replicon: chromosome
• Accession: NZ_CP068237
• Organism: Klebsiella quasipneumoniae strain YDKL-002

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JJQ56_RS13205
• Protein ID: WP_202025404.1
• Coordinates: 2717470..2718792 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JJQ56_RS13210
• Protein ID: WP_153678526.1
• Coordinates: 2718792..2719058 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJQ56_RS13170	2712574..2712792	+	219	WP_002904808.1	ParD-like family protein	-
JJQ56_RS13175	2712773..2713555	+	783	WP_202025399.1	type I methionyl aminopeptidase	-
JJQ56_RS13180	2713802..2714917	+	1116	WP_202025400.1	serine hydrolase	-
JJQ56_RS13185	2714904..2715248	+	345	WP_202025401.1	hypothetical protein	-
JJQ56_RS13190	2715277..2715810	+	534	WP_202025402.1	DUF2975 domain-containing protein	-
JJQ56_RS13195	2715813..2716019	+	207	WP_004205917.1	helix-turn-helix transcriptional regulator	-
JJQ56_RS13200	2716161..2717453	+	1293	WP_202025403.1	glycoside hydrolase family 10 protein	-
JJQ56_RS13205	2717470..2718792	-	1323	WP_202025404.1	type II toxin-antitoxin system HipA family toxin	Toxin
JJQ56_RS13210	2718792..2719058	-	267	WP_153678526.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JJQ56_RS13215	2719627..2719953	-	327	WP_153678525.1	hydroxyisourate hydrolase	-
JJQ56_RS13220	2719950..2720450	-	501	WP_202025405.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JJQ56_RS13225	2720428..2721807	-	1380	WP_017900377.1	purine permease	-
JJQ56_RS13230	2722153..2723307	+	1155	WP_202025406.1	FAD-dependent urate hydroxylase HpxO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49183.49 Da
• Isoelectric Point: 8.6110

>T186929 WP_202025404.1 NZ_CP068237:c2718792-2717470 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPREQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T186929 NZ_CP089775:72291-72692 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9926.36 Da
• Isoelectric Point: 7.1997

>AT186929 WP_153678526.1 NZ_CP068237:c2719058-2718792 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMVP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT186929 NZ_CP089775:72059-72298 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA