Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 733102..733883 Replicon chromosome
Accession NZ_CP068237
Organism Klebsiella quasipneumoniae strain YDKL-002

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag JJQ56_RS03620 Protein ID WP_202024588.1
Coordinates 733392..733883 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag JJQ56_RS03615 Protein ID WP_202025419.1
Coordinates 733102..733395 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ56_RS03595 728307..728909 - 603 WP_202024584.1 short chain dehydrogenase -
JJQ56_RS03600 729007..729918 + 912 WP_202024585.1 LysR family transcriptional regulator -
JJQ56_RS03605 729919..731067 - 1149 WP_202024586.1 PLP-dependent aspartate aminotransferase family protein -
JJQ56_RS03610 731078..732454 - 1377 WP_202024587.1 cystathionine beta-synthase -
JJQ56_RS03615 733102..733395 + 294 WP_202025419.1 DUF1778 domain-containing protein Antitoxin
JJQ56_RS03620 733392..733883 + 492 WP_202024588.1 GNAT family N-acetyltransferase Toxin
JJQ56_RS03625 733948..734646 + 699 WP_202024589.1 hypothetical protein -
JJQ56_RS03630 734761..736455 - 1695 WP_202024590.1 hypothetical protein -
JJQ56_RS03635 736452..738362 - 1911 WP_202024591.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.48 Da        Isoelectric Point: 6.8441

>T186919 WP_202024588.1 NZ_CP068237:733392-733883 [Klebsiella quasipneumoniae]
MISAPEPLHAGHILTPFCCGVESMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDDAREFYLRVGFEPSPMDPMMLMVTLGDLV
ESI

Download         Length: 492 bp

>T186919 NZ_CP089774:c3105328-3104972 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT186919 WP_202025419.1 NZ_CP068237:733102-733395 [Klebsiella quasipneumoniae]
MPAANSMTMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQAFLTRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT186919 NZ_CP089774:c3105542-3105312 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References