Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3972370..3973030 Replicon chromosome
Accession NZ_CP068234
Organism Leclercia adecarboxylata strain YZ30

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag JJN11_RS19120 Protein ID WP_103176874.1
Coordinates 3972370..3972783 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag JJN11_RS19125 Protein ID WP_103176875.1
Coordinates 3972764..3973030 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN11_RS19100 (JJN11_19020) 3968373..3970106 - 1734 WP_103176870.1 single-stranded-DNA-specific exonuclease RecJ -
JJN11_RS19105 (JJN11_19025) 3970112..3970825 - 714 WP_156655193.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJN11_RS19110 (JJN11_19030) 3970847..3971743 - 897 WP_103176872.1 site-specific tyrosine recombinase XerD -
JJN11_RS19115 (JJN11_19035) 3971844..3972365 + 522 WP_103176873.1 flavodoxin FldB -
JJN11_RS19120 (JJN11_19040) 3972370..3972783 - 414 WP_103176874.1 protein YgfX Toxin
JJN11_RS19125 (JJN11_19045) 3972764..3973030 - 267 WP_103176875.1 FAD assembly factor SdhE Antitoxin
JJN11_RS19130 (JJN11_19050) 3973334..3974314 + 981 WP_156655194.1 tRNA-modifying protein YgfZ -
JJN11_RS19135 (JJN11_19055) 3974400..3975059 - 660 WP_103176877.1 hemolysin III family protein -
JJN11_RS19140 (JJN11_19060) 3975225..3975536 - 312 WP_103176878.1 N(4)-acetylcytidine aminohydrolase -
JJN11_RS19145 (JJN11_19065) 3975589..3976320 + 732 WP_103176879.1 MurR/RpiR family transcriptional regulator -
JJN11_RS19150 (JJN11_19070) 3976435..3977868 + 1434 WP_156655195.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16236.07 Da        Isoelectric Point: 10.7511

>T186917 WP_103176874.1 NZ_CP068234:c3972783-3972370 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAAVILLMPWPLSYTPLWLMLLSLVVFDSVRSQRRINARQGEIKLFMDSRLHWQES
EWEIVGTPWMLNSGMMLRLRKGAGQRCHHLWLAADSMDEAEWRDLRRMMSHQPTQGR

Download         Length: 414 bp

>T186917 NZ_CP089774:c3065391-3064975 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10503.97 Da        Isoelectric Point: 4.8382

>AT186917 WP_103176875.1 NZ_CP068234:c3973030-3972764 [Leclercia adecarboxylata]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKHLFVRLLENDDPDLFNWLMNHGKPADAELQRMVLLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT186917 NZ_CP089774:c3065654-3065388 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References