Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2327149..2328711 Replicon chromosome
Accession NZ_CP068234
Organism Leclercia adecarboxylata strain YZ30

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JJN11_RS11305 Protein ID WP_156654481.1
Coordinates 2327149..2328456 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JJN11_RS11310 Protein ID WP_156654482.1
Coordinates 2328460..2328711 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN11_RS11290 (JJN11_11245) 2322662..2323843 - 1182 WP_156654478.1 PLP-dependent aminotransferase family protein -
JJN11_RS11295 (JJN11_11250) 2323977..2325971 - 1995 WP_156654479.1 TonB-dependent receptor -
JJN11_RS11300 (JJN11_11255) 2325982..2327043 - 1062 WP_156654480.1 YncE family protein -
JJN11_RS11305 (JJN11_11260) 2327149..2328456 - 1308 WP_156654481.1 type II toxin-antitoxin system HipA family toxin Toxin
JJN11_RS11310 (JJN11_11265) 2328460..2328711 - 252 WP_156654482.1 helix-turn-helix domain-containing protein Antitoxin
JJN11_RS11315 (JJN11_11270) 2329526..2333317 + 3792 WP_156654483.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48481.79 Da        Isoelectric Point: 6.6630

>T186908 WP_156654481.1 NZ_CP068234:c2328456-2327149 [Leclercia adecarboxylata]
MRAQRLTVAMNGEVVGTLHRDGSGAMSFQYAPEWLAEPGARAISLSLPLQHGRIRGKQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGLEIPSVMDIVAEPLDDEQIASLLEGYQMAPLGMSEEGADFRISLAGAQEKT
ALLWYQDRWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHAEMATFSRKKVLIIERFDRRW
ASSGWLMRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAQDREMFFKAQILFWMLAAIDGHGKNFSLFIEA
DSSFRMAPLYDVISAFPLFEAGSIPAKKAKMAMALQGKNRQYHFAMIQPRHFISTAAHAGFSQEIARRLMKEMADRTDEA
IATVRAELPADFPEQISEAIFRGLVSQAARISRFD

Download         Length: 1308 bp

>T186908 NZ_CP089774:c2366457-2366023 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9238.53 Da        Isoelectric Point: 8.6793

>AT186908 WP_156654482.1 NZ_CP068234:c2328711-2328460 [Leclercia adecarboxylata]
MKVTSAGALAQAVKDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILSALDLELHVVKRGSTLPDHASWT
KEW

Download         Length: 252 bp

>AT186908 NZ_CP089774:c2366718-2366464 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References